Next Article in Journal
Assessment of Fecundity and Germ Line Transmission in Two Transgenic Pig Lines Produced by Sleeping Beauty Transposition
Next Article in Special Issue
The Influence of Competition Among C. elegans Small RNA Pathways on Development
Previous Article in Journal
Genome Sequence of Azospirillum brasilense CBG497 and Comparative Analyses of Azospirillum Core and Accessory Genomes provide Insight into Niche Adaptation
Previous Article in Special Issue
Regulation of Fibroblast Growth Factor-2 Expression and Cell Cycle Progression by an Endogenous Antisense RNA
Article Menu

Export Article

Open AccessReview
Genes 2012, 3(4), 603-614;

Hints of tRNA-Derived Small RNAs Role in RNA Silencing Mechanisms

Laboratory of Functional Genomics, Institute Pasteur of Montevideo, Mataojo 2020, Montevideo 11400, Uruguay
Department of Medicine, Hospital de Clínicas, Av. Italia s/n, Montevideo 11400, Uruguay
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Received: 24 August 2012 / Revised: 26 September 2012 / Accepted: 28 September 2012 / Published: 10 October 2012
(This article belongs to the Special Issue RNA Interference)
Full-Text   |   PDF [400 KB, uploaded 10 October 2012]   |  


With the advent of new and improved high-throughput sequencing technologies in the last few years, a growing number of novel classes of small RNA, other than miRNAs or siRNA, has emerged, which appear as new actors in gene expression regulation. tRNA-derived small RNAs represent one of these novel members that are, surprisingly, among the most conserved class of small RNAs throughout evolution. They could represent the most primitive small RNA pathways from which the well-known canonical RNA silencing pathways reported in higher eukaryotes evolved. This review aims to make a compilation of the most relevant research literature in this field with the purpose of shedding light on the relation of these primitive tRNA-derived molecules with the gene silencing machinery. View Full-Text
Keywords: tRNAs; small RNAs; RNAi tRNAs; small RNAs; RNAi

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Garcia-Silva, M.R.; Cabrera-Cabrera, F.; Güida, M.C.; Cayota, A. Hints of tRNA-Derived Small RNAs Role in RNA Silencing Mechanisms. Genes 2012, 3, 603-614.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Genes EISSN 2073-4425 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top