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Genes, Volume 16, Issue 4

April 2025 - 114 articles

Cover Story: Limited genetic diversity, popular sire effects, and common ancestry can lead to increased homozygosity in purebred dogs. Breeding goals to maintain breed-defining characteristics and remove deleterious traits may also increase homozygosity. Inbreeding, which increases homozygosity, is associated with reduced health traits. To counter increased homozygosity, it has been suggested that breeding decisions should include measures of genetic diversity. In the past, breeders utilized pedigrees in mate choice for desirable traits, whereas now, there are DNA-based measures of diversity. In this study, we compared coefficients of inbreeding for a Bearded Collie population using pedigree data and DNA-based data to assess the different measures of genetic diversity. We also asked if the variation present would be expected to have a functional impact. View this paper
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Articles (114)

  • Article
  • Open Access
1 Citations
768 Views
21 Pages

Genome-Wide Identification and Expression Pattern Analysis of SBP Gene Family in Neolamarckia cadamba

  • Linhan Tang,
  • Keying Li,
  • Chuqing Cai,
  • Wenjun Wu,
  • Guichen Jian,
  • Ziming Lei,
  • Changcao Peng and
  • Jianmei Long

17 April 2025

Background: SQUAMOSA promoter-binding protein (SBP) genes encode a group of plant-specific transcription factors that play crucial roles in plant growth, development, and stress responses. To date, SBP genes have been reported in a number of plant sp...

  • Case Report
  • Open Access
1 Citations
1,141 Views
10 Pages

Loose Anagen Hair Associated with Wooly Hair Caused by a Heterozygous, Intronic KRT71 Variant

  • Elizabeth Phillippi,
  • Marcelo Melo,
  • Kelly N. Messingham and
  • Hatem El-Shanti

17 April 2025

Background: Loose anagen hair syndrome is a recently described genetic form of non-scarring alopecia that occurs in children and is due to poorly anchored hair shafts during the anagen phase. It can occur alone or in association with hair pathology o...

  • Article
  • Open Access
2 Citations
2,517 Views
18 Pages

Genetic Features of Tumours Arising in the Context of Suspected Hereditary Cancer Syndromes with RAD50, RAD51C/D, and BRIP1 Germline Mutations, Results of NGS-Reanalysis of BRCA/MMR-Negative Families

  • Mónica Arranz-Ledo,
  • Mar Infante,
  • Enrique Lastra,
  • Amaya Olaverri,
  • Marta Orozco,
  • Lucia C. Mateo,
  • Noemí Martínez,
  • Lara Hernández and
  • Mercedes Durán

16 April 2025

Background and Objectives: Despite the well-established role of the BRCA and mismatch repair (MMR) genes in DNA damage repair pathways, a substantial proportion of familial cancer cases still lack pathogenic variants in those genes. Next Generation S...

  • Article
  • Open Access
1 Citations
1,002 Views
13 Pages

16 April 2025

Background/Objectives: Freshwater shrimps of the family Atyidae, particularly the hyperdiverse genus Caridina, are keystone decomposers in tropical aquatic ecosystems and valuable aquaculture resources. However, their evolutionary relationships remai...

  • Article
  • Open Access
1,032 Views
20 Pages

IL-6 Affects Liver Metabolic Abnormalities Caused by Silicon Exposure by Regulating the PKC/YY1 Signaling Pathway

  • Hui Zhao,
  • Huihui Tao,
  • Jian Gao,
  • Jingjing Wang,
  • Guangliang Hui,
  • Ye Zhu,
  • Jialin Wang,
  • Xuansheng Ding and
  • Yong Dai

16 April 2025

Background: This study aims to investigate the impact of coal dust (silicon dioxide) exposure on dyslipidemia and its underlying mechanisms, with a focus on the association between coal dust exposure and hepatic metabolic disorders. Methods: Clinical...

  • Article
  • Open Access
909 Views
15 Pages

Inferring the Degree of Relatedness and Kinship Types Using an All-in-One Marker Set

  • Ran Li,
  • Yu Zang,
  • Jiajun Liu,
  • Enlin Wu,
  • Riga Wu and
  • Hongyu Sun

15 April 2025

Background/Objectives: Kinship inference is commonly adopted in various forensic applications, but previous studies have often lacked precision. Methods: In this study, a new method for the nomenclature of kinship types, i.e., kinship chain (KC), was...

  • Article
  • Open Access
1 Citations
2,842 Views
18 Pages

Population-Specific Differences in Pathogenic Variants of Genes Associated with Monogenic Parkinson’s Disease

  • Victor Flores-Ocampo,
  • Amanda Wei-Yin Lim,
  • Natalia S. Ogonowski,
  • Luis M. García-Marín,
  • Jue-Sheng Ong,
  • Dennis Yeow,
  • Claudia Gonzaga-Jauregui,
  • Kishore R. Kumar and
  • Miguel E. Rentería

15 April 2025

Background: Parkinson’s disease (PD) is a genetically complex neurodegenerative disorder. Up to 15% of cases are considered monogenic. However, research on monogenic PD has largely focused on populations of European ancestry, leaving gaps in ou...

  • Article
  • Open Access
1 Citations
1,258 Views
16 Pages

Association of ABC Efflux Transporter Genetic Variants and Adverse Drug Reactions and Survival in Patients with Non-Small Lung Cancer

  • Cecilia Souto Seguin,
  • Giovana Fernanda Santos Fidelis,
  • Carolina Dagli-Hernandez,
  • Pedro Eduardo Nascimento Silva Vasconcelos,
  • Mariana Vieira Morau,
  • Yasmim Gabriele Matos,
  • Maurício Wesley Perroud,
  • Eder de Carvalho Pincinato and
  • Patricia Moriel

15 April 2025

Background/Objectives: Lung cancer has a high mortality rate worldwide, with non-small cell lung cancer (NSCLC) being the most prevalent. Carboplatin and paclitaxel are key treatments for NSCLC; however, adverse drug reactions (ADRs) pose significant...

  • Article
  • Open Access
2 Citations
1,847 Views
19 Pages

Deciphering Gut Microbiome in Colorectal Cancer via Robust Learning Methods

  • Huiye Han,
  • Ying Li,
  • Youran Qi,
  • Stefano Mangiola and
  • Wodan Ling

15 April 2025

Background: Colorectal cancer (CRC) is one of the most prevalent cancers worldwide and is closely linked to the gut microbiota. Identifying reproducible and generalizable microbial signatures holds significant potential for enhancing early detection...

  • Article
  • Open Access
1,098 Views
17 Pages

Identification and Expression Analysis of Chalcone Synthase Gene Family in Tartary Buckwheat

  • Qinghai Wang,
  • Yanhua Jia,
  • Xin Lin,
  • Lu Tan,
  • Hanmei Du and
  • Anhu Wang

14 April 2025

Background: Chalcone synthase (CHS) functions as a pivotal and initiating enzyme in the flavonoid biosynthesis pathway within plants, playing a crucial role in the accumulation and metabolic processes of flavonoids. Despite its importance, there has...

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Genes - ISSN 2073-4425