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Genes, Volume 13, Issue 10

October 2022 - 241 articles

Cover Story: Malaria, caused by Plasmodium parasites, is still one of the biggest global health challenges. In recent years, epitranscriptomics is emerging as a new regulatory layer of gene expression. We present evidence of the variety of tRNA and mRNA modifications that are being characterized in Plasmodium spp., and the dynamic changes in their abundance during parasite development and cell fate. We end up outlining that new biological systems, such as the mosquito model, to decipher the unknowns about epigenetic mechanisms in vivo, and novel methodologies, to study the function of RNA modifications, are needed to discover the Achilles heel of the parasite. With this new knowledge, future strategies manipulating the epigenetics and epitranscriptomic machinery of the parasite have the potential of providing new weapons against malaria. View this paper
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Articles (241)

  • Article
  • Open Access
5 Citations
3,577 Views
18 Pages

20 October 2022

Sida cordifolia is a medicinal shrub that is conventionally used in the Indian system of medicine;however, the genes contributing to its medicinal properties have been minimally explored, thus limiting its application. High-throughputsequencing and L...

  • Article
  • Open Access
2 Citations
2,132 Views
15 Pages

Interactions between Environmental Factors and Glutathione S-Transferase (GST) Genes with Respect to Detectable Blood Aluminum Concentrations in Jamaican Children

  • Mohammad H. Rahbar,
  • Maureen Samms-Vaughan,
  • Yuansong Zhao,
  • Sepideh Saroukhani,
  • Jan Bressler,
  • Manouchehr Hessabi,
  • Megan L. Grove,
  • Sydonnie Shakespeare-Pellington and
  • Katherine A. Loveland

20 October 2022

Aluminum (Al) is a metallic toxicant at high concentrations following natural or unnatural exposures. Dietary intake is considered as the main source of aluminum exposure in children. We used data from 366 typically developing (TD) children (ages 2&n...

  • Article
  • Open Access
11 Citations
2,933 Views
21 Pages

20 October 2022

The ichthyofauna of continental islands is characterized by immigration through a land bridge due to fluctuating sea levels. Hainan Island is adjacent to the southern margin of mainland China and provides opportunities for understanding the origin an...

  • Article
  • Open Access
3 Citations
3,737 Views
19 Pages

Genome-Wide Identification of Potential mRNAs in Drought Response in Wheat (Triticum aestivum L.)

  • Muhammad Aqeel,
  • Wajya Ajmal,
  • Quratulain Mujahid,
  • Maryam Murtaza,
  • Mansour Almuqbil,
  • Shakira Ghazanfar,
  • Muhammad Uzair,
  • Ayesha Wadood,
  • Syed Mohammed Basheeruddin Asdaq and
  • Rameesha Abid
  • + 2 authors

20 October 2022

Plant cell metabolism inevitably forms an important drought-responsive mechanism, which halts crop productivity. Globally, more than 30% of the total harvested area was affected by dehydration. RNA-seq technology has enabled biologists to identify st...

  • Article
  • Open Access
3 Citations
2,781 Views
9 Pages

Postoperative Hypocalcemia following Non-Cardiac Surgical Procedures in Children with 22q11.2 Deletion Syndrome

  • Jill M. Arganbright,
  • Meghan Tracy,
  • Max Feldt,
  • Srivats Narayanan,
  • Ashna Mahadev and
  • Janelle Noel-MacDonnell

20 October 2022

The guidelines for management of children with 22q11.2 deletion syndrome (22q11DS) highlight the risk for developing hypocalcemia after surgery and recommend monitoring calcium perioperatively. Despite this guidance, little has been published on post...

  • Article
  • Open Access
7 Citations
2,854 Views
15 Pages

Adaptive Response and Transcriptomic Analysis of Flax (Linum usitatissimum L.) Seedlings to Salt Stress

  • Yuandong Li,
  • Jiao Chen,
  • Xiao Li,
  • Haixia Jiang,
  • Dongliang Guo,
  • Fang Xie,
  • Zeyang Zhang and
  • Liqiong Xie

20 October 2022

Soil salinity constrains agricultural development in arid regions. Flax is an economically important crop in many countries, and screening or breeding salinity-resistant flax cultivars is necessary. Based on the previous screening of flaxseed cultiva...

  • Article
  • Open Access
8 Citations
3,156 Views
17 Pages

19 October 2022

Flat stem and witches’ broom phytoplasma-like symptoms in the cucumber inbred line C17 were observed in a greenhouse at Yangzhou University, China for three consecutive planting seasons; these symptoms resulted in a decreased yield. To better u...

  • Article
  • Open Access
3 Citations
2,281 Views
10 Pages

Identification of Candidate Genes for Twinning Births in Dezhou Donkeys by Detecting Signatures of Selection in Genomic Data

  • Taifeng Xie,
  • Shuer Zhang,
  • Wei Shen,
  • Guoliang Zhang,
  • Rong Guo,
  • Wei Zhang,
  • Yanhang Cao,
  • Qingjie Pan,
  • Fengxin Liu and
  • Yujiang Sun
  • + 1 author

19 October 2022

Twinning trait in donkeys is an important manifestation of high fecundity, but few reports are available elucidating its genetic mechanism. To explore the genetic mechanism underlying the twin colt trait in Dezhou donkeys, DNA from 21 female Dezhou d...

  • Review
  • Open Access
17 Citations
5,666 Views
16 Pages

Mesenchymal-Stem-Cell-Based Strategies for Retinal Diseases

  • Xiteng Chen,
  • Yuanfeng Jiang,
  • Yanan Duan,
  • Xiaomin Zhang and
  • Xiaorong Li

19 October 2022

Retinal diseases are major causes of irreversible vision loss and blindness. Despite extensive research into their pathophysiology and etiology, pharmacotherapy effectiveness and surgical outcomes remain poor. Based largely on numerous preclinical st...

  • Article
  • Open Access
8 Citations
4,171 Views
12 Pages

A Novel De Novo NFKBIA Missense Mutation Associated to Ectodermal Dysplasia with Dysgammaglobulinemia

  • Chai Teng Chear,
  • Bader Abdul Kader El Farran,
  • Marina Sham,
  • Kavetha Ramalingam,
  • Lokman Mohd Noh,
  • Intan Hakimah Ismail,
  • Mei Yee Chiow,
  • Mohd Farid Baharin,
  • Adiratna Mat Ripen and
  • Saharuddin Bin Mohamad

19 October 2022

Background: Inborn errors of immunity (IEIs) are comprised of heterogeneous groups of genetic disorders affecting immune function. In this report, a 17-month-old Malay patient suspected of having Hyper IgM syndrome, a type of IEIs, was described. How...

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Genes - ISSN 2073-4425