Table of Contents
Cells, Volume 7, Issue 3 (March 2018)
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Cover Story (view full-size image) Cell identity and physiology is determined by differential gene expression, controlled in part by [...] Read more. Cell identity and physiology is determined by differential gene expression, controlled in part by the post-translational modification of core histones of nucleosomes, the smallest unit of chromatin. Mono- and tri-methylation of lysine 4 of histone H3 are associated with accessible, active enhancers and promoters, respectively, and with transcription. These modifications are catalyzed by KMT2/MLL methyltransferases, which are organized in six different complexes. Here, we discuss how distinct KMT2 complexes are selectively recruited to specific sites in chromatin. View this paper