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Cells 2018, 7(3), 20; https://doi.org/10.3390/cells7030020

Integrin Activation: Implications for Axon Regeneration

1
John van Geest Centre for Brain Repair, University of Cambridge, Cambridge CB2 0PY, UK
2
Centre for Developmental Neurobiology, King’s College London, London SE1 1UL, UK
3
Department of Biological Sciences, University of Southampton, Life Sciences Bldg 85, Highfield Campus, Southampton SO17 1BJ, UK
*
Author to whom correspondence should be addressed.
Received: 4 January 2018 / Revised: 1 March 2018 / Accepted: 9 March 2018 / Published: 10 March 2018
(This article belongs to the Special Issue Cell Adhesion Molecules)
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Abstract

Integrin activation is essential for creating functional transmembrane receptors capable of inducing downstream cellular effects such as cell migration, cell spreading, neurite outgrowth and axon regeneration. Integrins are bidirectional signalling molecules that mediate their effects by ‘inside–out’ and ‘outside–in’ signalling. This review will provide a detailed overview of integrin activation focusing on intracellular activation in neurons and discussing direct implications in the regulation of neurite outgrowth and axon regeneration. View Full-Text
Keywords: extracellular matrix; gene therapy; integrin activation; kindlin; regeneration; talin; tenascin extracellular matrix; gene therapy; integrin activation; kindlin; regeneration; talin; tenascin
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Cheah, M.; Andrews, M.R. Integrin Activation: Implications for Axon Regeneration. Cells 2018, 7, 20.

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