Special Issue "Cell Adhesion Molecules"
Deadline for manuscript submissions: 30 November 2018
Cell adhesion molecules are fundamental regulators of the structure and function of most tissues and organs. Their numerous physiological roles have expanded over recent decades to include the regulation of barrier function, polarity, cell-cell and cell-matrix communication, neural transmission, stem cell renewal, cell division and immune function to name but a few. Pathophysiologically speaking, dysregulation of adhesion molecule signaling has been implicated in conditions from cancer to inflammation to cognitive impairment. This Special Issue of Cells will advance our understanding of the upstream regulators and downstream targets of cell adhesion molecules, and the cellular mechanisms allowing them act as active drivers of various physiological and pathophysiological processes. Original contributions are welcome from authors actively engaged in the fields of cell–cell adhesion, cell–matrix adhesion and leukocyte adhesion, as well as from authors interested in emerging adhesion-independent signaling events associated with cell adhesion molecules. All models of study and all disease states will be considered, including systems biology approaches that provide new insight into the fundamental regulation of adhesion signaling.
We look forward to your contributions.Dr. Ann Hopkins
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- cell-cell junctions
- cell-matrix junctions
- tight junctions
- adherens junctions
- intercellular adhesion
- cell adhesion molecules
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Authors: Houreld N.N., Ayuk S.M. and Abrahamse H.
Affiliation: Laser Research Centre, Faculty of Health Sciences, University of Johannesburg, P.O. Box 17011, Doornfontein, Johannesburg, 2028, South Africa Tel: +27 11 559-6833 Fax +27 11 559-6884
Tentative title: Cell Adhesion Molecules are Mediated by Photobiomodulation at 660 nm in Diabetic Wounded Fibroblast Cells
Abstract: Diabetes is a metabolic disorder identified by hyperglycaemia. It may affect gene expression and extracellular matrix (ECM) metabolism, contributing to delayed wound healing and leading to chronic ulcers and amputations. Diabetic foot ulcers require extensive treatment and impact heavily on patient’s quality of life. Application of lasers and light (photobiomodulation, PBM) has been shown to improve diabetic wound healing; however, the underlying mechanisms are poorly understood. This study aimed to evaluate the influence of PBM at 660 nm on various cell adhesion molecules (CAMs) in diabetic wound healing. Human skin fibroblasts (WS1) were grouped into three models; normal (unstressed), wounded (stressed) and diabetic wounded (stressed). A continuous wave diode laser at 660 nm with a fluence of 5 J/cm2 was used for irradiation and cells were analysed 48 h post-irradiation. Controls consisted of sham-irradiated (0 J/cm2) cells. Real-time reverse transcription (RT) quantitative polymerase chain reaction (qPCR) was used to determine the expression of a variety of CAM related genes. Thirteen genes were up-regulated in normal cells, 15 in normal wounded cells and 7 in diabetic wounded cells, meanwhile four genes were down-regulated in normal cells, three genes in normal wounded cells, and 11 in diabetic wounded cells. Genes were related to transmembrane molecules, cell-cell adhesion, and cell-matrix adhesion. PBM at 660 nm modulated gene expression of various CAMs contributing to the increased healing seen in clinical practice. There is a need for new therapies to improve diabetic wound healing. The application of PBM alongside other clinical therapies may be very beneficial in treatment.