Special Issue "Receptor Tyrosine Kinases in Health and Disease"
Deadline for manuscript submissions: closed (28 February 2019).
Interests: cell surface receptors; transmembrane signaling; receptor tyrosine kinases; learning and memory; decision-making; animal behavior
Receptor tyrosine kinases (RTKs) play essential roles in cellular processes, including metabolism, cell-cycle control, survival, proliferation, motility and differentiation. RTKs are all synthesized as single-pass transmembrane proteins and bind polypeptide ligands, mainly growth factors. There are a number of mechanisms by which the tight regulation of TRK signaling can be abrogated, including enhanced production of ligands, overproduction of TRK proteins, mutations leading constitutive activation of TRK, deficiency of TRK downregulation, and activation of TRK through cross-talk with heterologous cell-surface receptors. Dysregulation of these processes directly links to disease in humans. Small molecule inhibitors are widely used that can target RTK functionality in disease. Antibodies that inhibit RTKs have also been developed, and are in current use or development in the clinic.
The aim of this Special Issues of Cells is to offer an Open Access collection of reviews on forefront research on RTKs that covers all the above aspects.
Prof. Dr. Ichiro Maruyama
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- anti-tumor drug
- developmental syndrome
- growth factor
- mental disorder
- monoclonal antibody
- preformed dimer
- receptor tyrosine kinase
- signal transduction
- small chemical inhibitor
- transmembrane signaling