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Cells, Volume 14, Issue 1

January-1 2025 - 60 articles

Cover Story: Astrocytes are active partners of neurons in brain function and dysfunction. While some brain circuits have been extensively studied from an astrocentric perspective, others, such as the dopaminergic circuit of the Ventral Tegmental Area (VTA), have received less attention. In this study, Speggiorin et al. applied two-photon imaging techniques to explore the Ca2+ response of astrocytes in the VTA to the catecholamine norepinephrine (NE), identifying the α1 adrenergic receptor as the main mediator of the astrocyte response. In mice lacking the IP3 receptor type-2, the authors found that the residual Ca2+ response to NE still depends on the release of Ca2+ from the endoplasmic reticulum. Overall, these results call for a re-examination of the interpretations of the mechanisms underlying the effects of NE in this brain circuit. View this paper
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Articles (60)

  • Article
  • Open Access
1 Citations
1,818 Views
15 Pages

Potassium Current Signature of Neuronal/Glial Progenitors in Amniotic Fluid Stem Cells

  • Paola Sabbatini,
  • Sabrina Cipriani,
  • Andrea Biagini,
  • Luana Sallicandro,
  • Cataldo Arcuri,
  • Rita Romani,
  • Paolo Prontera,
  • Alessandra Mirarchi,
  • Rosaria Gentile and
  • Diletta Del Bianco
  • + 8 authors

4 January 2025

Amniotic fluid is a complex and dynamic biological matrix that surrounds the fetus during the pregnancy. From this fluid, is possible to isolate various cell types with particular interest directed towards stem cells (AF-SCs). These cells are highly...

  • Review
  • Open Access
7 Citations
5,254 Views
33 Pages

4 January 2025

Retinitis pigmentosa (RP) is a hereditary disease characterized by progressive vision loss ultimately leading to blindness. This condition is initiated by mutations in genes expressed in retinal cells, resulting in the degeneration of rod photorecept...

  • Article
  • Open Access
2 Citations
2,606 Views
17 Pages

Circulating T Cell Subsets in Type 1 Diabetes

  • Aldo Ferreira-Hermosillo,
  • Paola Santana-Sánchez,
  • Ricardo Vaquero-García,
  • Manuel R. García-Sáenz,
  • Angélica Castro-Ríos,
  • Adriana K. Chávez-Rueda,
  • Rita A. Gómez-Díaz,
  • Luis Chávez-Sánchez and
  • María V. Legorreta-Haquet

4 January 2025

Type 1 diabetes (T1D) is a complex disease driven by the immune system attacking the insulin-producing beta cells in the pancreas. Understanding the role of different T cell subpopulations in the development and progression of T1D is crucial. By empl...

  • Review
  • Open Access
5 Citations
7,667 Views
27 Pages

3 January 2025

Amyotrophic Lateral Sclerosis (ALS) is a complex neurodegenerative disease primarily affecting motor neurons, leading to progressive muscle atrophy and paralysis. This review explores the role of Schwann cells in ALS pathogenesis, highlighting their...

  • Article
  • Open Access
1,970 Views
14 Pages

3 January 2025

Parasitoid elimination in Drosophila melanogaster involves special hemocytes, called lamellocytes, which encapsulate the eggs or larvae of the parasitoid wasps. The capsules are melanized, and metabolites of the melanization reaction may play a poten...

  • Article
  • Open Access
3 Citations
2,493 Views
21 Pages

TGFβ1 Restores Energy Homeostasis of Human Trophoblast Cells Under Hyperglycemia In Vitro by Inducing PPARγ Expression, AMPK Activation, and HIF1α Degradation

  • Nihad Khiat,
  • Julie Girouard,
  • Emmanuelle Stella Kana Tsapi,
  • Cathy Vaillancourt,
  • Céline Van Themsche and
  • Carlos Reyes-Moreno

3 January 2025

Elevated glucose levels at the fetal–maternal interface are associated with placental trophoblast dysfunction and increased incidence of pregnancy complications. Trophoblast cells predominantly utilize glucose as an energy source, metabolizing...

  • Article
  • Open Access
8 Citations
3,338 Views
22 Pages

New Insights in Microplastic Cellular Uptake Through a Cell-Based Organotypic Rainbow-Trout (Oncorhynchus mykiss) Intestinal Platform

  • Nicole Verdile,
  • Nico Cattaneo,
  • Federica Camin,
  • Matteo Zarantoniello,
  • Federico Conti,
  • Gloriana Cardinaletti,
  • Tiziana A. L. Brevini,
  • Ike Olivotto and
  • Fulvio Gandolfi

3 January 2025

Microplastics (MPs) in fish can cross the intestinal barrier and are often bioaccumulated in several tissues, causing adverse effects. While the impacts of MPs on fish are well documented, the mechanisms of their cellular internalization remain uncle...

  • Review
  • Open Access
5,373 Views
27 Pages

p63: A Master Regulator at the Crossroads Between Development, Senescence, Aging, and Cancer

  • Lakshana Sruthi Sadu Murari,
  • Sam Kunkel,
  • Anala Shetty,
  • Addison Bents,
  • Aayush Bhandary and
  • Juan Carlos Rivera-Mulia

3 January 2025

The p63 protein is a master regulatory transcription factor that plays crucial roles in cell differentiation, adult tissue homeostasis, and chromatin remodeling, and its dysregulation is associated with genetic disorders, physiological and premature...

  • Review
  • Open Access
6 Citations
4,569 Views
18 Pages

3 January 2025

Huntington’s disease (HD) is an inherited neurodegenerative disease characterized by uncontrolled movements, emotional disturbances, and progressive cognitive impairment. It is estimated to affect 4.3 to 10.6 per 100,000 people worldwide, and t...

  • Review
  • Open Access
1 Citations
3,114 Views
19 Pages

CAR-T Therapy Beyond B-Cell Hematological Malignancies

  • Martina Canichella and
  • Paolo de Fabritiis

3 January 2025

Despite the advances of CAR-T cells in certain hematological malignancies, mostly from B-cell derivations such as non-Hodgkin lymphomas, acute lymphoblastic leukemia and multiple myeloma, a significant portion of other hematological and non-hematolog...

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Cells - ISSN 2073-4409