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Cells
Volume 11
Issue 13
10.3390/cells11132028
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Review

The Role of the Immune System in the Development of Endometriosis

by
Monika Abramiuk
1,
Ewelina Grywalska
2,
Paulina Małkowska
3,4,
Olga Sierawska
3,4,
Rafał Hrynkiewicz
3 and
Paulina Niedźwiedzka-Rystwej
3,*
1
Department of Gynecological Oncology and Gynecology, Medical University of Lublin, 20-081 Lublin, Poland
2
Department of Experimental Immunology, Medical University of Lublin, 20-093 Lublin, Poland
3
Institute of Biology, University of Szczecin, 71-412 Szczecin, Poland
4
Doctoral School, University of Szczecin, 71-412 Szczecin, Poland
*
Author to whom correspondence should be addressed.
Cells 2022, 11(13), 2028; https://doi.org/10.3390/cells11132028
Submission received: 27 May 2022 / Revised: 19 June 2022 / Accepted: 23 June 2022 / Published: 25 June 2022
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Abstract

Endometriosis is a chronic disease that affects about 10% of women of reproductive age. It can contribute to pelvic pain, infertility or other conditions such as asthma, cardiovascular disease, breast or ovarian cancer. Research has shown that one of the conditions for the development of endometrial lesions is the dysfunction of the immune system. It appears that immune cells, such as neutrophils, macrophages, NK cells and dendritic cells, may play a specific role in the angiogenesis, growth and invasion of endometriosis cells. Immune cells secrete cytokines and defensins that also affect the endometriosis environment. This review discusses the various components of the immune system that are involved in the formation of endometrial lesions in women.
Keywords: endometriosis; immune system; cytokine; defensins endometriosis; immune system; cytokine; defensins

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MDPI and ACS Style

Abramiuk, M.; Grywalska, E.; Małkowska, P.; Sierawska, O.; Hrynkiewicz, R.; Niedźwiedzka-Rystwej, P. The Role of the Immune System in the Development of Endometriosis. Cells 2022, 11, 2028. https://doi.org/10.3390/cells11132028

AMA Style

Abramiuk M, Grywalska E, Małkowska P, Sierawska O, Hrynkiewicz R, Niedźwiedzka-Rystwej P. The Role of the Immune System in the Development of Endometriosis. Cells. 2022; 11(13):2028. https://doi.org/10.3390/cells11132028

Chicago/Turabian Style

Abramiuk, Monika, Ewelina Grywalska, Paulina Małkowska, Olga Sierawska, Rafał Hrynkiewicz, and Paulina Niedźwiedzka-Rystwej. 2022. "The Role of the Immune System in the Development of Endometriosis" Cells 11, no. 13: 2028. https://doi.org/10.3390/cells11132028

APA Style

Abramiuk, M., Grywalska, E., Małkowska, P., Sierawska, O., Hrynkiewicz, R., & Niedźwiedzka-Rystwej, P. (2022). The Role of the Immune System in the Development of Endometriosis. Cells, 11(13), 2028. https://doi.org/10.3390/cells11132028

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