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Enzymatic Synthesis and Characterization of Thermosensitive Polyester with Pendent Ketoprofen

Key Laboratory of Green Chemistry & Technology (Ministry of Education), College of Chemistry, Sichuan University, Chengdu 610064, China
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Polymers 2013, 5(3), 1158-1168; https://doi.org/10.3390/polym5031158
Received: 8 August 2013 / Revised: 2 September 2013 / Accepted: 9 September 2013 / Published: 23 September 2013
Three linear polyesters with pendant ketoprofen were synthesized by copolymerization of polyethylene glycol (PEG) with malic acid (thiomalic acid or aspartic acid) using lipase B acrylic resin from Candida antarctica (CAL-B) at 90 °C respectively. These thermosensitive polyesters exhibit a lower critical solution temperature (LCST) at 10–12 °C. The in vitro study demonstrated that these polyesters could release ketoprofen in neutral and alkaline medium but showed hydrolytic stability in acid medium. These results suggest that, with pendant drugs, these thermosensitive polyesters have potential applications in biomedical materials. View Full-Text
Keywords: enzymatic synthesis; CAL-B; thermosensitive polyester; ketoprofen; PEG enzymatic synthesis; CAL-B; thermosensitive polyester; ketoprofen; PEG
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MDPI and ACS Style

Wu, W.-X.; Wang, H.-Y.; Wang, N.; Zhang, W.-W.; Lai, H.; Yu, X.-Q. Enzymatic Synthesis and Characterization of Thermosensitive Polyester with Pendent Ketoprofen. Polymers 2013, 5, 1158-1168. https://doi.org/10.3390/polym5031158

AMA Style

Wu W-X, Wang H-Y, Wang N, Zhang W-W, Lai H, Yu X-Q. Enzymatic Synthesis and Characterization of Thermosensitive Polyester with Pendent Ketoprofen. Polymers. 2013; 5(3):1158-1168. https://doi.org/10.3390/polym5031158

Chicago/Turabian Style

Wu, Wan-Xia, Hai-Yang Wang, Na Wang, Wei-Wei Zhang, Han Lai, and Xiao-Qi Yu. 2013. "Enzymatic Synthesis and Characterization of Thermosensitive Polyester with Pendent Ketoprofen" Polymers 5, no. 3: 1158-1168. https://doi.org/10.3390/polym5031158

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