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Polymers 2018, 10(2), 109; https://doi.org/10.3390/polym10020109

Collagen-Coated Poly(lactide-co-glycolide)/Hydroxyapatite Scaffold Incorporated with DGEA Peptide for Synergistic Repair of Skull Defect

1
Department of General Dentistry, School and Hospital of Stomatology, Jilin University, Changchun 130021, China
2
Department of Thyroid Surgery, The First Hospital of Jilin University, Changchun 130021, China
3
VIP Integrated Department, School and Hospital of Stomatology, Jilin University, Changchun 130021, China
4
Department of Orthopedics, Zhongshan Hospital Affiliated to Xiamen University, Xiamin 361004, China
5
Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
*
Authors to whom correspondence should be addressed.
Received: 30 November 2017 / Revised: 16 January 2018 / Accepted: 18 January 2018 / Published: 24 January 2018
(This article belongs to the Special Issue Polymer Scaffolds for Biomedical Application)
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Abstract

The treatment of large-area bone defects remains a challenge; however, various strategies have been developed to improve the performances of scaffolds in bone tissue engineering. In this study, poly(lactide-co-glycolide)/hydroxyapatite (PLGA/HA) scaffold was coated with Asp-Gly-Glu-Ala (DGEA)-incorporated collagen for the repair of rat skull defect. Our results indicated that the mechanical strength and hydrophilicity of the PLGA/HA scaffold were clearly improved and conducive to cell adhesion and proliferation. The collagen-coated scaffold with DGEA significantly promoted the repair of skull defect. These findings indicated that a combination of collagen coating and DGEA improved scaffold properties for bone regeneration, thereby providing a new potential strategy for scaffold design. View Full-Text
Keywords: porous scaffold; collagen coating; bioactive peptide; skull defect repair; tissue engineering porous scaffold; collagen coating; bioactive peptide; skull defect repair; tissue engineering
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Bi, M.; Han, H.; Dong, S.; Zhang, Y.; Xu, W.; Zhu, B.; Wang, J.; Zhou, Y.; Ding, J. Collagen-Coated Poly(lactide-co-glycolide)/Hydroxyapatite Scaffold Incorporated with DGEA Peptide for Synergistic Repair of Skull Defect. Polymers 2018, 10, 109.

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