Collagen-Coated Poly(lactide-co-glycolide)/Hydroxyapatite Scaffold Incorporated with DGEA Peptide for Synergistic Repair of Skull Defect

Bi, Ming; Han, Hui; Dong, Shujun; Zhang, Ying; Xu, Weiguo; Zhu, Bitao; Wang, Jingyun; Zhou, Yanmin; Ding, Jianxun

doi:10.3390/polym10020109

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Collagen-Coated Poly(lactide-co-glycolide)/Hydroxyapatite Scaffold Incorporated with DGEA Peptide for Synergistic Repair of Skull Defect

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Department of General Dentistry, School and Hospital of Stomatology, Jilin University, Changchun 130021, China

Department of Thyroid Surgery, The First Hospital of Jilin University, Changchun 130021, China

VIP Integrated Department, School and Hospital of Stomatology, Jilin University, Changchun 130021, China

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Department of Orthopedics, Zhongshan Hospital Affiliated to Xiamen University, Xiamin 361004, China

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Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China

Authors to whom correspondence should be addressed.

Polymers 2018, 10(2), 109; https://doi.org/10.3390/polym10020109

Received: 30 November 2017 / Revised: 16 January 2018 / Accepted: 18 January 2018 / Published: 24 January 2018

(This article belongs to the Special Issue Polymer Scaffolds for Biomedical Application)

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Abstract

The treatment of large-area bone defects remains a challenge; however, various strategies have been developed to improve the performances of scaffolds in bone tissue engineering. In this study, poly(lactide-co-glycolide)/hydroxyapatite (PLGA/HA) scaffold was coated with Asp-Gly-Glu-Ala (DGEA)-incorporated collagen for the repair of rat skull defect. Our results indicated that the mechanical strength and hydrophilicity of the PLGA/HA scaffold were clearly improved and conducive to cell adhesion and proliferation. The collagen-coated scaffold with DGEA significantly promoted the repair of skull defect. These findings indicated that a combination of collagen coating and DGEA improved scaffold properties for bone regeneration, thereby providing a new potential strategy for scaffold design. View Full-Text

Keywords: porous scaffold; collagen coating; bioactive peptide; skull defect repair; tissue engineering

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MDPI and ACS Style

Bi, M.; Han, H.; Dong, S.; Zhang, Y.; Xu, W.; Zhu, B.; Wang, J.; Zhou, Y.; Ding, J. Collagen-Coated Poly(lactide-co-glycolide)/Hydroxyapatite Scaffold Incorporated with DGEA Peptide for Synergistic Repair of Skull Defect. Polymers 2018, 10, 109. https://doi.org/10.3390/polym10020109

AMA Style

Bi M, Han H, Dong S, Zhang Y, Xu W, Zhu B, Wang J, Zhou Y, Ding J. Collagen-Coated Poly(lactide-co-glycolide)/Hydroxyapatite Scaffold Incorporated with DGEA Peptide for Synergistic Repair of Skull Defect. Polymers. 2018; 10(2):109. https://doi.org/10.3390/polym10020109

Chicago/Turabian Style

Bi, Ming, Hui Han, Shujun Dong, Ying Zhang, Weiguo Xu, Bitao Zhu, Jingyun Wang, Yanmin Zhou, and Jianxun Ding. 2018. "Collagen-Coated Poly(lactide-co-glycolide)/Hydroxyapatite Scaffold Incorporated with DGEA Peptide for Synergistic Repair of Skull Defect" Polymers 10, no. 2: 109. https://doi.org/10.3390/polym10020109

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Collagen-Coated Poly(lactide-co-glycolide)/Hydroxyapatite Scaffold Incorporated with DGEA Peptide for Synergistic Repair of Skull Defect

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