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Article

Hyaluronic Acid-Coated MTX-PEI Nanoparticles for Targeted Rheumatoid Arthritis Therapy

1
Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, Hunan, China
2
School of Medicine, Yichun University, Yichun 336000, Jiangxi, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Duane Choquesillo-Lazarte
Crystals 2021, 11(4), 321; https://doi.org/10.3390/cryst11040321
Received: 26 February 2021 / Revised: 20 March 2021 / Accepted: 22 March 2021 / Published: 24 March 2021
Methotrexate (MTX) is an anchor drug for the treatment of rheumatoid arthritis (RA); however, long-term and high-dose usage of MTX for patients can cause many side effects and toxic reactions. To address these difficulties, selectively delivering MTX to the inflammatory site of a joint is promising in the treatment of RA. In this study, we prepared [email protected] nanoparticles (NPs), composed of hyaluronic acid (HA) as the hydrophilic negative electrical shell, and MTX-linked branched polyethyleneimine (MTX-PEI) NPs as the core. [email protected] NPs were prepared in the water phase by a one-pot method. The polymeric NPs were selectively internalized via CD44 receptor-mediated endocytosis in the activated macrophages. In the in vivo mice mode study, treatment with [email protected] NPs mitigated inflammatory arthritis with notable safety at a high dose of MTX. We highlight the distinct advantages of aqueous-synthesized NPs coated with HA for arthritis-selective targeted delivery, thus verifying [email protected] NPs as a promising MTX-based nanoplatform for treatment of RA. View Full-Text
Keywords: methotrexate; polyethyleneimine; rheumatoid arthritis; nanoparticles; target therapy methotrexate; polyethyleneimine; rheumatoid arthritis; nanoparticles; target therapy
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MDPI and ACS Style

Zhong, S.; Liu, P.; Ding, J.; Zhou, W. Hyaluronic Acid-Coated MTX-PEI Nanoparticles for Targeted Rheumatoid Arthritis Therapy. Crystals 2021, 11, 321. https://doi.org/10.3390/cryst11040321

AMA Style

Zhong S, Liu P, Ding J, Zhou W. Hyaluronic Acid-Coated MTX-PEI Nanoparticles for Targeted Rheumatoid Arthritis Therapy. Crystals. 2021; 11(4):321. https://doi.org/10.3390/cryst11040321

Chicago/Turabian Style

Zhong, Shenghui, Peng Liu, Jinsong Ding, and Wenhu Zhou. 2021. "Hyaluronic Acid-Coated MTX-PEI Nanoparticles for Targeted Rheumatoid Arthritis Therapy" Crystals 11, no. 4: 321. https://doi.org/10.3390/cryst11040321

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