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Regional Delivery of Chimeric Antigen Receptor (CAR) T-Cells for Cancer Therapy

Department of Surgery, Boston University, Boston, MA 02118, USA
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Author to whom correspondence should be addressed.
Academic Editor: Vita Golubovskaya
Cancers 2017, 9(7), 92; https://doi.org/10.3390/cancers9070092
Received: 9 June 2017 / Revised: 8 July 2017 / Accepted: 11 July 2017 / Published: 18 July 2017
(This article belongs to the Special Issue CAR-T Cell Therapy against Different Types of Cancer)
Chimeric Antigen Receptor (CAR) T-cells are T-cells with recombinant receptors targeted to tumor antigens. CAR-T cell therapy has emerged as a mode of immunotherapy and is now being extensively explored in hematologic cancer. In contrast, CAR-T cell use in solid tumors has been hampered by multiple obstacles. Several approaches have been taken to circumvent these obstacles, including the regional delivery of CAR-T cells. Regional CAR-T cell delivery can theoretically compensate for poor T-cell trafficking and tumor antigen specificity while avoiding systemic toxicity associated with intravenous delivery. We reviewed completed clinical trials for the treatment of glioblastoma and metastatic colorectal cancer and examined the data in these studies for safety, efficacy, and potential advantages that regional delivery may confer over systemic delivery. Our appraisal of the available literature revealed that regional delivery of CAR-T cells in both glioblastoma and hepatic colorectal metastases was generally well tolerated and efficacious in select instances. We propose that the regional delivery of CAR-T cells is an area of potential growth in the solid tumor immunotherapy, and look towards future clinical trials in head and neck cancer, mesothelioma, and peritoneal carcinomatosis as the use of this technique expands. View Full-Text
Keywords: Chimeric Antigen Receptor T-Cell delivery; CAR-T; regional CAR-T delivery; solid tumor immunotherapy Chimeric Antigen Receptor T-Cell delivery; CAR-T; regional CAR-T delivery; solid tumor immunotherapy
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Sridhar, P.; Petrocca, F. Regional Delivery of Chimeric Antigen Receptor (CAR) T-Cells for Cancer Therapy. Cancers 2017, 9, 92.

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