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Head and Neck Sarcomas: A Comprehensive Cancer Center Experience
Division of Hematology/Oncology, University of Rochester Medical Center, Rochester, NY 14642, USA
Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
* Author to whom correspondence should be addressed.
Received: 20 May 2013; in revised form: 20 May 2013 / Accepted: 18 June 2013 / Published: 15 July 2013
Abstract: Head/neck sarcomas are rare, accounting for about 1% of head/neck malignancies and 5% of sarcomas. Outcomes have historically been worse in this group, due to anatomic constraints leading to difficulty in completely excising tumors, with high rates of local recurrence. We retrospectively analyzed cases of head/neck soft tissue sarcomas (STS) and osteogenic sarcomas managed in a multi-disciplinary setting at Fox Chase Cancer Center from 1999–2009 to describe clinicopathologic characteristics, treatment, outcomes, and prognostic factors for disease control and survival. Thirty patients with STS and seven patients with osteogenic sarcoma were identified. Most STS were high grade (23) and almost all were localized at presentation (28). Common histologies were synovial cell (6), rhabdomyosarcoma (5), angiosarcoma (4), liposarcoma (4) and leiomyosarcoma (3). The type of primary therapy and disease outcomes were analyzed. Cox proportional hazards regression analysis was performed to identify predictors of disease-free survival (DFS) and overall survival (OS). The HR and 95% CI for Cox model and median DFS/OS analyzed by Kaplan-Meier curves were calculated.
Keywords: head and neck sarcomas; soft tissue sarcomas; osteogenic sarcomas
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Tejani, M.A.; Galloway, T.J.; Lango, M.; Ridge, J.A.; von Mehren, M. Head and Neck Sarcomas: A Comprehensive Cancer Center Experience. Cancers 2013, 5, 890-900.
Tejani MA, Galloway TJ, Lango M, Ridge JA, von Mehren M. Head and Neck Sarcomas: A Comprehensive Cancer Center Experience. Cancers. 2013; 5(3):890-900.
Tejani, Mohamedtaki A.; Galloway, Thomas J.; Lango, Miriam; Ridge, John A.; von Mehren, Margaret. 2013. "Head and Neck Sarcomas: A Comprehensive Cancer Center Experience." Cancers 5, no. 3: 890-900.