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Angiogenesis and Melanoma

Department of Human Anatomy and Histology, University of Bari Medical School, Piazza G. Cesare, 11, Policlinico 70124, Bari, Italy
Author to whom correspondence should be addressed.
Cancers 2010, 2(1), 114-132;
Received: 11 January 2010 / Revised: 10 February 2010 / Accepted: 24 February 2010 / Published: 25 February 2010
(This article belongs to the Special Issue Current Concepts in the Diagnosis and Treatment of Cutaneous Melanoma)
PDF [476 KB, uploaded 25 February 2010]


Angiogenesis occurs in pathological conditions, such as tumors, where a specific critical point in tumor progression is the transition from the avascular to the vascular phase. Tumor angiogenesis depends mainly on the release by neoplastic cells of growth factors specific for endothelial cells, which are able to stimulate the growth of the host’s blood vessels. This article summarizes the literature concerning the relationship between angiogenesis and human melanoma progression. The recent applications of antiangiogenic agents which interfere with melanoma progression are also described. View Full-Text
Keywords: angiogenesis; antiangiogenesis; human melanoma; tumor progression angiogenesis; antiangiogenesis; human melanoma; tumor progression
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Ribatti, D.; Annese, T.; Longo, V. Angiogenesis and Melanoma. Cancers 2010, 2, 114-132.

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