Effect of Vitamin D Supplements on Relapse of Digestive Tract Cancer with Tumor Stromal Immune Response: A Secondary Analysis of the AMATERASU Randomized Clinical Trial
Abstract
:Simple Summary
Abstract
1. Introduction
2. Materials and Methods
2.1. Trial Design
2.2. Participants
2.3. Outcomes
2.4. Tissue Microarray
2.5. Immunohistochemistry
2.6. Image Analysis and Scoring
2.7. Evaluation of Other Covariates
2.8. Statistical Analysis
3. Results
3.1. Study Population
3.2. Image Analyses
3.3. Patients’ Characteristics
3.4. Effects of Interactions between Vitamin D and Immune Cells on Relapse
3.5. Effects of Interactions between Vitamin D and Immune Cells on Relapse or Death
3.6. Effects of Interactions between Vitamin D and Immune Cells on Death
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Akutsu, T.; Kanno, K.; Okada, S.; Ohdaira, H.; Suzuki, Y.; Urashima, M. Effect of Vitamin D Supplements on Relapse of Digestive Tract Cancer with Tumor Stromal Immune Response: A Secondary Analysis of the AMATERASU Randomized Clinical Trial. Cancers 2021, 13, 4708. https://doi.org/10.3390/cancers13184708
Akutsu T, Kanno K, Okada S, Ohdaira H, Suzuki Y, Urashima M. Effect of Vitamin D Supplements on Relapse of Digestive Tract Cancer with Tumor Stromal Immune Response: A Secondary Analysis of the AMATERASU Randomized Clinical Trial. Cancers. 2021; 13(18):4708. https://doi.org/10.3390/cancers13184708
Chicago/Turabian StyleAkutsu, Taisuke, Kazuki Kanno, Shinya Okada, Hironori Ohdaira, Yutaka Suzuki, and Mitsuyoshi Urashima. 2021. "Effect of Vitamin D Supplements on Relapse of Digestive Tract Cancer with Tumor Stromal Immune Response: A Secondary Analysis of the AMATERASU Randomized Clinical Trial" Cancers 13, no. 18: 4708. https://doi.org/10.3390/cancers13184708