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Cancers, Volume 13, Issue 11

June-1 2021 - 344 articles

Cover Story: Tumor progression, therapy resistance and metastasis are profoundly controlled by the tumor microenvironment. Endothelial cell contribution to tumor progression was initially only attributed to the formation of new blood vessels (angiogenesis). However, endothelial cells do not only provide conduits for blood transportation but also express numerous membrane-bound and secreted factors. Such angiocrine functions promote aggressiveness of cancer cells, influence the immune response towards cancer cells and thereby contribute to tumor progression and metastasis. Crosstalk between endothelial cells and cancer cells contributes to the cancer stem cell phenotype, epithelial to mesenchymal transition, immunosuppression, remodeling of the extracellular matrix and intravasation of cancer cells into the bloodstream in primary tumor but also at the pre-metastatic niche and metastasis. View this paper
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Articles (344)

  • Article
  • Open Access
15 Citations
4,524 Views
20 Pages
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RAD51D Aberrant Splicing in Breast Cancer: Identification of Splicing Regulatory Elements and Minigene-Based Evaluation of 53 DNA Variants

  • Elena Bueno-Martínez,
  • Lara Sanoguera-Miralles,
  • Alberto Valenzuela-Palomo,
  • Víctor Lorca,
  • Alicia Gómez-Sanz,
  • Sara Carvalho,
  • Jamie Allen,
  • Mar Infante,
  • Pedro Pérez-Segura and
  • Conxi Lázaro
  • + 5 authors
Cancers2021, 13(11), 2845;https://doi.org/10.3390/cancers13112845

7 June 2021

RAD51D loss-of-function variants increase lifetime risk of breast and ovarian cancer. Splicing disruption is a frequent pathogenic mechanism associated with variants in susceptibility genes. Herein, we have assessed the splicing and clinical impact o...

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  • Article
  • Open Access
41 Citations
5,323 Views
16 Pages
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Molecular Classification to Prognosticate Response in Medically Managed Endometrial Cancers and Endometrial Intraepithelial Neoplasia

  • Allison M. Puechl,
  • Daniel Spinosa,
  • Andrew Berchuck,
  • Angeles Alvarez Secord,
  • Kerry E. Drury,
  • Gloria Broadwater,
  • Janice Wong,
  • Regina Whitaker,
  • Nicolas Devos and
  • David L. Corcoran
  • + 2 authors
Cancers2021, 13(11), 2847;https://doi.org/10.3390/cancers13112847

7 June 2021

Background: The aim of this study was to evaluate whether molecular classification prognosticates treatment response in women with endometrial cancers and endometrial intraepithelial neoplasia (EIN) treated with levonorgestrel intrauterine system (LN...

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  • Article
  • Open Access
16 Citations
4,330 Views
13 Pages
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Trend Shifts in Age-Specific Incidence for In Situ and Invasive Cutaneous Melanoma in Sweden

  • Hanna Eriksson,
  • Kari Nielsen,
  • Ismini Vassilaki,
  • Jan Lapins,
  • Rasmus Mikiver,
  • Johan Lyth and
  • Karolin Isaksson
Cancers2021, 13(11), 2838;https://doi.org/10.3390/cancers13112838

7 June 2021

Background: The incidence of invasive cutaneous melanoma (CM) is increasing in Sweden. The aim was to present age- and sex-specific trends of the age-standardised incidence and the average annual percentage change (AAPC) for in situ and invasive CM....

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  • Article
  • Open Access
19 Citations
3,587 Views
13 Pages
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Hyperspectral Imaging (HSI)—A New Tool to Estimate the Perfusion of Upper Abdominal Organs during Pancreatoduodenectomy

  • Yusef Moulla,
  • Dorina Christin Buchloh,
  • Hannes Köhler,
  • Sebastian Rademacher,
  • Timm Denecke,
  • Hans-Jonas Meyer,
  • Matthias Mehdorn,
  • Undine Gabriele Lange,
  • Robert Sucher and
  • Daniel Seehofer
  • + 2 authors
Cancers2021, 13(11), 2846;https://doi.org/10.3390/cancers13112846

7 June 2021

Hyperspectral imaging (HSI) in abdominal surgery is a new non-invasive tool for the assessment of the perfusion and oxygenation of various tissues and organs. Its benefit in pancreatic surgery is still unknown. The aim of this study was to evaluate t...

Full Article
  • Article
  • Open Access
12 Citations
4,476 Views
13 Pages
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Identification of Nucleolin as a Novel AEG-1-Interacting Protein in Breast Cancer via Interactome Profiling

  • Seong-Jae Lee,
  • Kyoung-Min Choi,
  • Geul Bang,
  • Seo-Gyu Park,
  • Eun-Bi Kim,
  • Jin-Woong Choi,
  • Young-Ho Chung,
  • Jinyoung Kim,
  • Seok-Geun Lee and
  • Eunjung Kim
  • + 1 author
Cancers2021, 13(11), 2842;https://doi.org/10.3390/cancers13112842

7 June 2021

Breast cancer is one of the most common malignant diseases worldwide. Astrocyte elevated gene-1 (AEG-1) is upregulated in breast cancer and regulates breast cancer cell proliferation and invasion. However, the molecular mechanisms by which AEG-1 prom...

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  • Article
  • Open Access
14 Citations
4,694 Views
16 Pages
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Circulating Levels of the Interferon-γ-Regulated Chemokines CXCL10/CXCL11, IL-6 and HGF Predict Outcome in Metastatic Renal Cell Carcinoma Patients Treated with Antiangiogenic Therapy

  • Emilio Esteban,
  • Francisco Exposito,
  • Guillermo Crespo,
  • Julio Lambea,
  • Alvaro Pinto,
  • Javier Puente,
  • Jose A. Arranz,
  • Miriam Redrado,
  • Cristina Rodriguez-Antona and
  • Carlos de Andrea
  • + 8 authors
Cancers2021, 13(11), 2849;https://doi.org/10.3390/cancers13112849

7 June 2021

Sunitinib and pazopanib are standard first-line treatments for patients with metastatic renal cell carcinoma (mRCC). Nonetheless, as the number of treatment options increases, there is a need to identify biomarkers that can predict drug efficacy and...

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  • Article
  • Open Access
22 Citations
4,077 Views
14 Pages
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Identification of a Two-MicroRNA Signature in Plasma as a Novel Biomarker for Very Early Diagnosis of Breast Cancer

  • Anna Adam-Artigues,
  • Iris Garrido-Cano,
  • Juan Antonio Carbonell-Asins,
  • Ana Lameirinhas,
  • Soraya Simón,
  • Belén Ortega-Morillo,
  • María Teresa Martínez,
  • Cristina Hernando,
  • Vera Constâncio and
  • Octavio Burgues
  • + 6 authors
Cancers2021, 13(11), 2848;https://doi.org/10.3390/cancers13112848

7 June 2021

The early diagnosis of breast cancer is essential to improve patients’ survival rate. In this context, microRNAs have been described as potential diagnostic biomarkers for breast cancer. Particularly, circulating microRNAs have a strong value as non-...

Full Article
  • Article
  • Open Access
20 Citations
5,531 Views
28 Pages
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VDAC1 Silencing in Cancer Cells Leads to Metabolic Reprogramming That Modulates Tumor Microenvironment

  • Erez Zerbib,
  • Tasleem Arif,
  • Anna Shteinfer-Kuzmine,
  • Vered Chalifa-Caspi and
  • Varda Shoshan-Barmatz
Cancers2021, 13(11), 2850;https://doi.org/10.3390/cancers13112850

7 June 2021

The tumor microenvironment (TME) plays an important role in cell growth, proliferation, migration, immunity, malignant transformation, and apoptosis. Thus, better insight into tumor–host interactions is required. Most of these processes involve the m...

Full Article
  • Systematic Review
  • Open Access
7 Citations
4,096 Views
12 Pages
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Do Salivary Bypass Tubes Reduce the Risk of Pharyngocutaneous Fistula after Laryngopharyngectomy—A Systematic Review and Meta-Analysis

  • Blažen Marijić,
  • Stefan Grasl,
  • Matthaeus Ch. Grasl,
  • Muhammad Faisal,
  • Boban M. Erovic and
  • Stefan Janik
Cancers2021, 13(11), 2827;https://doi.org/10.3390/cancers13112827

6 June 2021

To evaluate the effect of salivary bypass tube (SBT) usage on the occurrence of pharyngocutaneous fistula (PCF) in patients after a laryngopharyngectomy, a total of 20 studies, published between 1988 and 2021, were identified including 2946 patients....

Full Article
  • Article
  • Open Access
11 Citations
4,582 Views
17 Pages
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Prospective SPECT-CT Organ Dosimetry-Driven Radiation-Absorbed Dose Escalation Using the In-111 (111In)/Yttrium 90 (90Y) Ibritumomab Tiuxetan (Zevalin®) Theranostic Pair in Patients with Lymphoma at Myeloablative Dose Levels

  • Richard L. Wahl,
  • Eric C. Frey,
  • Heather A. Jacene,
  • Brad S. Kahl,
  • Steven Piantadosi,
  • Jesus A. Bianco,
  • Richard J. Hammes,
  • Miah Jung,
  • Wayne Kasecamp and
  • Bin He
  • + 3 authors
Cancers2021, 13(11), 2828;https://doi.org/10.3390/cancers13112828

6 June 2021

Purpose: We prospectively evaluated the feasibility of SPECT-CT/planar organ dosimetry-based radiation dose escalation radioimmunotherapy in patients with recurrent non-Hodgkin’s lymphoma using the theranostic pair of 111In and 90Y anti-CD20 ibritumo...

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