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Micromachines, Volume 16, Issue 2
February 2025 - 129 articles
Cover Story: Intracortical microelectrode arrays (MEAs) are essential for recording neural signals, with them offering insights into both healthy and diseased states. However, their reliability for long-term recording is limited by the foreign body response (FBR), including gliosis and neuronal loss near implant sites. Using amorphous silicon carbide (a-SiC) MEAs with reduced cross-sectional areas, which enhances flexibility while maintaining implantation stiffness, we compared the performance of a-SiC MEAs to conventional silicon-based probes over a period of 16 weeks in the rat motor cortex. Our results demonstrate that a-SiC MEAs exhibit superior chronic recording performance, mitigate the FBR, and achieve higher active electrode yields. Our findings highlight the potential of a-SiC technology for stable, long-term neural interfaces, advancing applications in neuroprosthetics and neuromodulation. View this paper
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Micromachines - ISSN 2072-666XCreative Common CC BY license