Effect of Hemocoagulase on the Prevention of Bleeding after Percutaneous Renal Biopsy
Abstract
:1. Introduction
2. Results
2.1. Patient Characteristics
2.2. Factors Affecting Post Renal Biopsy Hb Decline
2.3. The Effect of Hemocoagulase on Post-Renal Biopsy Hb Decline in the Propensity Score-Matched Cohort
3. Discussion
4. Conclusions
5. Materials and Methods
5.1. Patient Selection and Study Design
5.2. Data Collection
5.3. Statistical Analysis
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Characteristic | All (n = 221) | Non-Hemocoagulase (n = 82) | Hemocoagulase (n = 139) | p-Value |
---|---|---|---|---|
Age (years) | 58 (42–70) | 59 (42–73) | 57 (42–68) | 0.17 |
Male (%) | 53.8 | 62.2 | 48.9 | 0.0558 |
AKI (%) | 5.4 | 7.3 | 4.3 | 0.34 |
BMI (kg/m2) | 22.0 (20.0–24.7) | 23.5 (20.6–25.6) | 21.4 (19.8–24.3) | 0.0158 |
Systolic BP (mmHg) | 127 (118–138) | 128 (117–137) | 126 (118–138) | 0.89 |
Diastolic BP (mmHg) | 77 (69–83) | 77 (70–83) | 78 (68–83) | 0.53 |
Hb (g/dL) | 12.1 (10.7–13.8) | 12.7 (11.1–14.0) | 11.8 (10.6–13.6) | 0.0231 |
Plt (×104/μL) | 25.5 (19.8–30.1) | 23.4 (19.4–29.5) | 25.8 (19.8–30.1) | 0.59 |
PT-INR | 0.98 (0.93–1.04) | 0.99 (0.94–1.03) | 0.98 (0.93–1.06) | 0.81 |
APTT (s) | 27.4 (25.0–30.2) | 26.6 (24.7–28.9) | 28.4 (25.1–31.8) | 0.014 |
TP (g/dL) | 7 (6.4–7.7) | 7.1 (6.3–7.6) | 7.0 (6.4–7.8) | 0.65 |
AST (U/L) | 20 (16–25) | 20 (16–24) | 20 (16–26) | 0.8 |
ALT (U/L) | 16 (11–22) | 16 (11–23) | 16 (12–21) | 0.79 |
BUN (mg/dL) | 17 (13–24) | 17 (12–25) | 16 (13–24) | 0.89 |
Cr (mg/dL) | 1.00 (0.77–1.46) | 0.99 (0.82–1.39) | 1.00 (0.73–1.48) | 0.46 |
eGFR (mL/min/1.73 m2) | 55.0 (37.1–72.6) | 52.4 (36.3–69.3) | 56.0 (37.2–79.0) | 0.54 |
Urinary protein (g/gCr) | 1.32 (0.51–4.16) | 1.35 (0.47–4.25) | 1.31 (0.54–3.91) | 0.93 |
Number of punctures | 3 (2–3) | 2 (2–3) | 3 (2–3) | 0.15 |
Post-biopsy Hb decline (g/dL) | 0.33 ± 0.84 | 0.50 ± 0.87 | 0.23 ± 0.80 | 0.0204 |
Post-biopsy Hb decline (%) | 2.52 ± 6.97 | 3.93 ± 6.74 | 1.69 ± 7.00 | 0.0208 |
Post-biopsy Hb decline ≥10% (%) | 13.1 | 15.9 | 11.5 | 0.36 |
Characteristic | Non-Hemocoagulase (n = 70) | Hemocoagulase (n = 70) | p-Value |
---|---|---|---|
Age (years) | 59.5 (41.3–73) | 61.5 (47.8–70) | 0.87 |
Male (%) | 55.7 | 61.4 | 0.49 |
AKI (%) | 5.7 | 4.3 | 0.7 |
BMI (kg/m2) | 23.1 (20.3–24.9) | 22.5 (20.1–25.6) | 0.86 |
Systolic BP (mmHg) | 128 (116–137) | 128.5 (121–139) | 0.41 |
Diastolic BP (mmHg) | 76 (69–82) | 78 (70–85) | 0.69 |
Hb (g/dL) | 12.5 ± 2.1 | 12.7 ± 1.9 | 0.56 |
Plt (×104/μL) | 25.8 (20.0–30.6) | 24.2 (19.3–28.7) | 0.2 |
PT-INR | 0.99 (0.94–1.03) | 0.97 (0.93–1.04) | 0.45 |
APTT (s) | 27.2 ± 3.3 | 27.1 ± 3.6 | 0.78 |
eGFR (mL/min/1.73 m2) | 54.5 ± 26.3 | 56.2 ± 24.5 | 0.69 |
Number of punctures | 2 (2–3) | 3 (2–3) | 0.48 |
Post-biopsy Hb decline (g/dL) | 0.56 ± 0.89 | 0.17 ± 0.74 | 0.006 |
Post-biopsy Hb decline (%) | 4.36 ± 6.85 | 1.29 ± 5.92 | 0.0054 |
Post-biopsy Hb decline ≥10% (%) | 18.6 | 7.1 | 0.0434 |
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Torigoe, K.; Yamashita, A.; Abe, S.; Muta, K.; Mukae, H.; Nishino, T. Effect of Hemocoagulase on the Prevention of Bleeding after Percutaneous Renal Biopsy. Toxins 2022, 14, 223. https://doi.org/10.3390/toxins14030223
Torigoe K, Yamashita A, Abe S, Muta K, Mukae H, Nishino T. Effect of Hemocoagulase on the Prevention of Bleeding after Percutaneous Renal Biopsy. Toxins. 2022; 14(3):223. https://doi.org/10.3390/toxins14030223
Chicago/Turabian StyleTorigoe, Kenta, Ayuko Yamashita, Shinichi Abe, Kumiko Muta, Hiroshi Mukae, and Tomoya Nishino. 2022. "Effect of Hemocoagulase on the Prevention of Bleeding after Percutaneous Renal Biopsy" Toxins 14, no. 3: 223. https://doi.org/10.3390/toxins14030223