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Toxins, Volume 11, Issue 9

September 2019 - 67 articles

Cover Story: Animal venoms, especially from spiders, are among the most promising sources of novel drug leads. However, the bioprospecting strategies for venoms need to be optimized in order to facilitate their economic implementation. In our study, we used the plethora of deposited tarantula toxins from public databases in tandem with published phylogenetic data to unravel understudied genetic lineages within the family and to determine priority groups for future bioprospecting studies. This rational taxon selection based on evolutionary relationships may be applied to other, likewise biodiverse yet venom-wise understudied taxa and could be helpful to economize and optimize venom bioprospecting across the metazoan tree of life. View this paper
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Articles (67)

  • Article
  • Open Access
9 Citations
5,237 Views
10 Pages

19 September 2019

Rice grains can be attacked by a range of pathogens, including Aspergillus species, which can cause the accumulation of aflatoxins and represent a serious threat to the consumers. Aflatoxins are secondary metabolites synthesized by Aspergillus specie...

  • Article
  • Open Access
15 Citations
5,646 Views
14 Pages

Genomic Analysis of Clostridium perfringens BEC/CPILE-Positive, Toxinotype D and E Strains Isolated from Healthy Children

  • Raymond Kiu,
  • Kathleen Sim,
  • Alex Shaw,
  • Emma Cornwell,
  • Derek Pickard,
  • J. Simon Kroll and
  • Lindsay J. Hall

19 September 2019

Clostridium perfringens toxinotype D, toxinotype E, and gastroenteritis-linked BEC/CPILE-positive strains have never been reported in healthy children. We isolated, whole-genome sequenced and bioinformatically characterised three C. perfringens isola...

  • Review
  • Open Access
20 Citations
6,965 Views
22 Pages

Inhibition of Pore-Forming Proteins

  • Neža Omersa,
  • Marjetka Podobnik and
  • Gregor Anderluh

19 September 2019

Perforation of cellular membranes by pore-forming proteins can affect cell physiology, tissue integrity, or immune response. Since many pore-forming proteins are toxins or highly potent virulence factors, they represent an attractive target for the d...

  • Article
  • Open Access
4 Citations
4,453 Views
17 Pages

19 September 2019

Venoms are comprised of diverse mixtures of proteins, peptides, and small molecules. Identifying individual venom components and their target(s) with mechanism of action is now attainable to understand comprehensively the effectiveness of venom cockt...

  • Review
  • Open Access
9 Citations
4,575 Views
11 Pages

19 September 2019

Patients with benign prostatic hyperplasia (BPH) can exhibit various lower urinary tract symptoms (LUTS) owing to bladder outlet obstruction (BOO), prostatic inflammation, and bladder response to BOO. The pathogenesis of BPH involves an imbalance of...

  • Article
  • Open Access
42 Citations
5,087 Views
14 Pages

Fumonisins at Doses below EU Regulatory Limits Induce Histological Alterations in Piglets

  • Chloé Terciolo,
  • Ana Paula Bracarense,
  • Pollyana C.M.C. Souto,
  • Anne-Marie Cossalter,
  • Léonie Dopavogui,
  • Nicolas Loiseau,
  • Carlos A. F. Oliveira,
  • Philippe Pinton and
  • Isabelle P. Oswald

19 September 2019

Fumonisins (FBs) are mycotoxins produced by Fusarium species that can contaminate human food and animal feed. Due to the harmful effects of FBs on animals, the European Union (EU) defined a recommendation of a maximum of 5 mg FBs (B1 + B2)/kg for com...

  • Article
  • Open Access
18 Citations
6,623 Views
22 Pages

Assessment of Dried Blood Spots for Multi-Mycotoxin Biomarker Analysis in Pigs and Broiler Chickens

  • Marianne Lauwers,
  • Siska Croubels,
  • Siegrid De Baere,
  • Milena Sevastiyanova,
  • Eva Maria Romera Sierra,
  • Ben Letor,
  • Christos Gougoulias and
  • Mathias Devreese

18 September 2019

Dried blood spots (DBSs), a micro-sampling technique whereby a drop of blood is collected on filter paper has multiple advantages over conventional blood sampling regarding the sampling itself, as well as transportation and storage. This is the first...

  • Article
  • Open Access
17 Citations
4,414 Views
12 Pages

Alkaloid Lindoldhamine Inhibits Acid-Sensing Ion Channel 1a and Reveals Anti-Inflammatory Properties

  • Dmitry I. Osmakov,
  • Sergey G. Koshelev,
  • Victor A. Palikov,
  • Yulia A. Palikova,
  • Elvira R. Shaykhutdinova,
  • Igor A. Dyachenko,
  • Yaroslav A. Andreev and
  • Sergey A. Kozlov

18 September 2019

Acid-sensing ion channels (ASICs), which are present in almost all types of neurons, play an important role in physiological and pathological processes. The ASIC1a subtype is the most sensitive channel to the medium’s acidification, and it play...

  • Article
  • Open Access
54 Citations
5,327 Views
15 Pages

Astaxanthin Protects OTA-Induced Lung Injury in Mice through the Nrf2/NF-κB Pathway

  • Weixiang Xu,
  • Mingyang Wang,
  • Gengyuan Cui,
  • Lin Li,
  • Danyang Jiao,
  • Beibei Yao,
  • Ketao Xu,
  • Yueli Chen,
  • Miao Long and
  • Shuhua Yang
  • + 1 author

17 September 2019

The aim of this research was to evaluate the potential protective mechanism of astaxanthin (ASTA) against oxidative damage and inflammation caused by ochratoxin (OTA) in mouse lung. We divided mice into a control group (CG), an OTA group (PG), an ast...

  • Article
  • Open Access
19 Citations
5,627 Views
12 Pages

Identification of a Novel Saxitoxin Analogue, 12β-Deoxygonyautoxin 3, in the Cyanobacterium, Anabaena circinalis (TA04)

  • Takashi Minowa,
  • Yuko Cho,
  • Yasukatsu Oshima,
  • Keiichi Konoki and
  • Mari Yotsu-Yamashita

16 September 2019

Saxitoxin (STX) and its analogues, the potent voltage-gated sodium channel blockers, are biosynthesized by freshwater cyanobacteria and marine dinoflagellates. We previously identified several biosynthetic intermediates in the extract of the cyanobac...

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Toxins - ISSN 2072-6651