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Cordyceps militaris Extract Protects Human Dermal Fibroblasts against Oxidative Stress-Induced Apoptosis and Premature Senescence

Department of Bioengineering and Technology, Kangwon National University, Chuncheon 200701, Korea
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These authors contributed equally to this work.
Nutrients 2014, 6(9), 3711-3726; https://doi.org/10.3390/nu6093711
Received: 11 June 2014 / Revised: 30 July 2014 / Accepted: 29 August 2014 / Published: 16 September 2014
Oxidative stress induced by reactive oxygen species (ROS) is the major cause of degenerative disorders including aging and disease. In this study, we investigated whether Cordyceps militaris extract (CME) has in vitro protective effects on hydrogen peroxide-induced oxidative stress in human dermal fibroblasts (HDFs). Our results showed that the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity of CME was increased in a dose-dependent manner. We found that hydrogen peroxide treatment in HDFs increased ROS generation and cell death as compared with the control. However, CME improved the survival of HDFs against hydrogen peroxide-induced oxidative stress via inhibition of intracellular ROS production. CME treatment inhibited hydrogen peroxide-induced apoptotic cell death and apoptotic nuclear condensation in HDFs. In addition, CME prevented hydrogen peroxide-induced SA-β-gal-positive cells suggesting CME could inhibit oxidative stress-induced premature senescence. Therefore, these results suggest that CME might have protective effects against oxidative stress-induced premature senescence via scavenging ROS. View Full-Text
Keywords: Cordyceps militaris; apoptosis; fibroblast; oxidative stress; senescence Cordyceps militaris; apoptosis; fibroblast; oxidative stress; senescence
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Park, J.M.; Lee, J.S.; Lee, K.R.; Ha, S.-J.; Hong, E.K. Cordyceps militaris Extract Protects Human Dermal Fibroblasts against Oxidative Stress-Induced Apoptosis and Premature Senescence. Nutrients 2014, 6, 3711-3726.

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