Tocotrienol-Rich Fraction and Levodopa Regulate Proteins Involved in Parkinson’s Disease-Associated Pathways in Differentiated Neuroblastoma Cells: Insights from Quantitative Proteomic Analysis
, Premdass Ramdas 3, Sushela Devi Somanath 4, Kanga Rani Selvaduray 5, Saatheeyavaane Bhuvanendran 1 and Ammu Kutty Radhakrishnan 1,6,*
Round 1
Reviewer 1 Report
See my comments in the attached PDF file.
Comments for author File: 
Comments.pdf
Author Response
Please see file attached
Author Response File: Author Response.pdf
Reviewer 2 Report
1) Getting to the conclusion that TRF exerts profound neuroprotective effects by regulating pathways that hamper the development of PD is too broad to make. To make that conclusion, there is a need to add more data with human patient-derived iPSC-derived neurons, patients' tissues, in vivo models, etc. to make that conclusion.
2) Figures are hard-to-read. Need to improve the resolution of the text.
2) Fig 5 has too much information and is difficult for readers to understand.
Author Response
Please see file attached
Author Response File: Author Response.pdf
