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Clinics and Practice
Volume 2
Issue 3
10.4081/cp.2012.e64
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Clinics and Practice is published by MDPI from Volume 11 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Case Report

Successful Treatment of HCV/HBV/HDV-Coinfection with Pegylated Interferon and Ribavirin

by
Janine Hartl
*,
Claudia Ott
,
Gabriele Kirchner
,
Bernd Salzberger
and
Reiner Wiest
Internal Medicine 1, University Hospital of Regensburg, Germany
*
Author to whom correspondence should be addressed.
Clin. Pract. 2012, 2(3), e64; https://doi.org/10.4081/cp.2012.e64
Submission received: 7 November 2011 / Revised: 26 April 2012 / Accepted: 7 May 2012 / Published: 10 July 2012

Abstract

Dual and triple infections with hepatitis virus C (HCV), B (HBV) and D (HDV) frequently lead to severe liver damage. Hereby we describe a 38-year-old Caucasian male coinfected with HCV (genotype 3a), HBV [positive hepatitis B surface antigen (HbsAg) and antibody to hepatitis B core antigen; negative hepatitis B e antigen (HbeAg) and antibody to hepatitis B e antigen (anti-HBe)] and HDV. Laboratory diagnostics revealed increased liver enzymes and histological examination of the liver showed signs of fibrosis with moderate inflammation. On therapy with pegIFN-a2b and ribavirin HCV-RNA was undetectable at week 8. After week 24 the antiviral therapy was stopped because of a HBs-seroconversion, the loss of HbeAg and the detection of anti-HBe. Furthermore the HCV-RNA was negative. Six months after successful treatment of the triple-infection, HCV- and HDV-RNA and HbsAg remained negative and the liver enzymes had been completely normalized. In conclusion, pegylated-interferon plus ribavirin may be an effective therapy for HCV, HBV and HDV-coinfected patients.
Keywords: HCV; HBV; HDV; triple-hepatitis; pegylated interferon; ribavirin HCV; HBV; HDV; triple-hepatitis; pegylated interferon; ribavirin

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MDPI and ACS Style

Hartl, J.; Ott, C.; Kirchner, G.; Salzberger, B.; Wiest, R. Successful Treatment of HCV/HBV/HDV-Coinfection with Pegylated Interferon and Ribavirin. Clin. Pract. 2012, 2, e64. https://doi.org/10.4081/cp.2012.e64

AMA Style

Hartl J, Ott C, Kirchner G, Salzberger B, Wiest R. Successful Treatment of HCV/HBV/HDV-Coinfection with Pegylated Interferon and Ribavirin. Clinics and Practice. 2012; 2(3):e64. https://doi.org/10.4081/cp.2012.e64

Chicago/Turabian Style

Hartl, Janine, Claudia Ott, Gabriele Kirchner, Bernd Salzberger, and Reiner Wiest. 2012. "Successful Treatment of HCV/HBV/HDV-Coinfection with Pegylated Interferon and Ribavirin" Clinics and Practice 2, no. 3: e64. https://doi.org/10.4081/cp.2012.e64

APA Style

Hartl, J., Ott, C., Kirchner, G., Salzberger, B., & Wiest, R. (2012). Successful Treatment of HCV/HBV/HDV-Coinfection with Pegylated Interferon and Ribavirin. Clinics and Practice, 2(3), e64. https://doi.org/10.4081/cp.2012.e64

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