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Thalassemia Reports, Volume 15, Issue 2

June 2025 - 3 articles

Cover Story: Patients with β-thalassemia are susceptible to systemic iron overload and recurrent infections. We investigated the interplay between iron metabolism and neutrophil function in individuals with β-thalassemia and sickle cell anemia. β-thalassemia patients showed marked iron overload, reduced neutrophil counts, and impaired oxidative burst as well as phagocytic activity. Systemic iron levels inversely correlated with neutrophil function. Gene expression analysis revealed the upregulation of iron transporters FPN1B and DMT1A in patient neutrophils. These findings highlight the detrimental impact of iron overload on neutrophil-mediated immunity in β-thalassemia. View this paper

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Articles (3)

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Case Report

1,234 Views

12 Pages

A Rare Case of High Physical Endurance in Transfusion-Dependent Thalassemia Patients with Poor Cardiac Functions

Nathasha Brigitta Selene,
Ayudra Fitrananda,
Natasha Yemima Situmorang,
Kamilia Rifani Ufairah,
Stephen Diah Iskandar and
Pustika Amalia Wahidiyat

Thalass. Rep.2025, 15(2), 6;https://doi.org/10.3390/thalassrep15020006

9 June 2025

Background/Objectives: Chronic anemia and iron overload in thalassemia lead to organ failures, including the heart, liver, endocrine glands, and spleen. Comprehensive multidisciplinary management is pivotal in improving patients’ clinical outco...

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Article

1,994 Views

10 Pages

Prevalence and Specificity of Red Blood Cell Alloimmunization: Insights from Transfusion-Dependent Populations in Serbia

Radovan Dinić,
Nevenka Bujandrić and
Jasmina Grujić

Thalass. Rep.2025, 15(2), 5;https://doi.org/10.3390/thalassrep15020005

7 May 2025

Background/Objectives: Red blood cell (RBC) alloimmunization is a significant challenge in transfusion medicine, particularly among transfusion-dependent patients, such as those with thalassemia. It arises from the production of antibodies against no...

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Article

893 Views

9 Pages

Dysregulation of Iron Homeostasis in β-Thalassemia and Impaired Neutrophil Activity

Sreenithi Santhakumar,
Leo Stephen,
Aruna Barade,
Uday Kulkarni,
Biju George and
Eunice S. Edison

Thalass. Rep.2025, 15(2), 4;https://doi.org/10.3390/thalassrep15020004

25 April 2025

Background/Objective: Patients with beta-thalassemia are more susceptible to iron overload and have altered neutrophil function. This study investigated the connections between iron metabolism in neutrophils, neutrophil functionality, and overall iro...

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Thalass. Rep. - ISSN 2039-4365

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