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Thalass. Rep., Volume 15, Issue 1 (March 2025) – 2 articles

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10 pages, 487 KiB  
Review
New Perspectives on the Impact of Iron Chelation Therapy on the Gut Microbiome in Thalassemia Patients
by Sara Deumić, Neira Crnčević, Mirsada Hukić, Muamer Dizdar and Monia Avdić
Thalass. Rep. 2025, 15(1), 2; https://doi.org/10.3390/thalassrep15010002 - 10 Feb 2025
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Abstract
Thalassemia, a genetic condition characterized by defective hemoglobin synthesis, is often managed with transfusion therapy, which can lead to iron overload—a significant contributor to morbidity and mortality due to organ damage and pathogenic infections. Iron chelation therapy, the cornerstone of managing iron toxicity, [...] Read more.
Thalassemia, a genetic condition characterized by defective hemoglobin synthesis, is often managed with transfusion therapy, which can lead to iron overload—a significant contributor to morbidity and mortality due to organ damage and pathogenic infections. Iron chelation therapy, the cornerstone of managing iron toxicity, may inadvertently influence the gut microbiome, a critical modulator of immunity and metabolism. This review provides new insights into the interplay between iron chelation therapy and gut microbiome dynamics in thalassemia patients. It synthesizes findings on how chelators such as deferoxamine, deferasirox, and deferiprone influence microbial composition, iron availability, and systemic inflammation. Emerging evidence highlights alterations in gut microbial diversity, with reduced beneficial taxa and increased pathogenic populations, driven by changes in luminal iron levels. This imbalance contributes to immune dysregulation, systemic inflammation, and susceptibility to infections. The review advocates for tailored treatment strategies that integrate microbiome-targeted interventions alongside traditional chelation therapy to improve patient outcomes. By combining genetic profiling, dietary adjustments, and microbiome modulation, this approach offers a promising avenue for personalized medicine in thalassemia care. Full article
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8 pages, 654 KiB  
Review
Acute Painful Transfusion Reactions (APTRs): A Comprehensive Review of Clinical Features, Pathophysiology, Diagnosis, and Management
by Sophia Delicou, Aspasia Argyrou, Sophia Mellou, Aikaterini Xydaki, Anthippi Gafou and Constantina Politis
Thalass. Rep. 2025, 15(1), 1; https://doi.org/10.3390/thalassrep15010001 - 31 Jan 2025
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Abstract
It is important to recognize the significance of acute painful transfusion reactions (APTRs) as a complication of blood transfusions. These adverse reactions are characterized by the onset of acute pain after the administration of blood components. Despite their potential to cause significant discomfort [...] Read more.
It is important to recognize the significance of acute painful transfusion reactions (APTRs) as a complication of blood transfusions. These adverse reactions are characterized by the onset of acute pain after the administration of blood components. Despite their potential to cause significant discomfort and distress to patients, these reactions are frequently disregarded and under-reported in clinical practice. This review aims to provide a comprehensive analysis of the clinical features, pathophysiology, diagnosis, incidence, and management of APTRs, emphasizing the necessity for heightened awareness and further research in this field. Full article
(This article belongs to the Section Innovative Treatment of Thalassemia)
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