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Neurology International
Volume 5
Issue 1
10.4081/ni.2013.e4
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Neurology International is published by MDPI from Volume 12 Issue 3 (2020). Previous articles were published by another publisher in Open Access under a CC-BY licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Article

Expression of B-Cell Activating Factor, a Proliferating Inducing Ligand and Its Receptors in Primary Central Nervous System Lymphoma

by
Tobias Birnbaum
1,*,
Sigrid Langer
1,
Sigrun Roeber
2,
Louisa von Baumgarten
1 and
Andreas Straube
1
1
Department of Neurology, Ludwig-Maximilians University, Munich
2
Department of Neuropathology, Ludwig-Maximilians University, Munich
*
Author to whom correspondence should be addressed.
Neurol. Int. 2013, 5(1), e4; https://doi.org/10.4081/ni.2013.e4
Submission received: 14 September 2012 / Revised: 12 February 2013 / Accepted: 25 February 2013 / Published: 21 March 2013

Abstract

B-cell activating factor belonging to the tumor necrosis factor family (BAFF) and a proliferating inducing ligand (APRIL) might play an important role in the pathogenesis of systemic B-cell malignancies. However, the BAFF/APRIL system has not been systematically evaluated in primary central nervous system lymphoma (PCNSL) to date. We assessed the expression of BAFF, APRIL and its receptors BAFF-R (BAFF receptor), BCMA (B-cell maturation antigen) and TACI (transmembrane activator and calcium modulator cyclophilin ligand interactor) in five PCNSL specimens by immunohistochemical staining. We found extensive expression of BAFF and weak to moderate expression of APRIL, BAFF-R, BCMA, and TACI in all specimens. CD20 positive cells showed expression of both ligands and receptors at the same time. Our results indicate that autocrine stimulation of the BAFF/APRIL system might be involved in the pathogenesis of PCNSL.
Keywords: PCNSL; BAFF; APRIL; TACI; BCMA PCNSL; BAFF; APRIL; TACI; BCMA

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MDPI and ACS Style

Birnbaum, T.; Langer, S.; Roeber, S.; von Baumgarten, L.; Straube, A. Expression of B-Cell Activating Factor, a Proliferating Inducing Ligand and Its Receptors in Primary Central Nervous System Lymphoma. Neurol. Int. 2013, 5, e4. https://doi.org/10.4081/ni.2013.e4

AMA Style

Birnbaum T, Langer S, Roeber S, von Baumgarten L, Straube A. Expression of B-Cell Activating Factor, a Proliferating Inducing Ligand and Its Receptors in Primary Central Nervous System Lymphoma. Neurology International. 2013; 5(1):e4. https://doi.org/10.4081/ni.2013.e4

Chicago/Turabian Style

Birnbaum, Tobias, Sigrid Langer, Sigrun Roeber, Louisa von Baumgarten, and Andreas Straube. 2013. "Expression of B-Cell Activating Factor, a Proliferating Inducing Ligand and Its Receptors in Primary Central Nervous System Lymphoma" Neurology International 5, no. 1: e4. https://doi.org/10.4081/ni.2013.e4

APA Style

Birnbaum, T., Langer, S., Roeber, S., von Baumgarten, L., & Straube, A. (2013). Expression of B-Cell Activating Factor, a Proliferating Inducing Ligand and Its Receptors in Primary Central Nervous System Lymphoma. Neurology International, 5(1), e4. https://doi.org/10.4081/ni.2013.e4

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