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Neurology International
Volume 5
Issue 2
10.4081/ni.2013.e6
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Neurology International is published by MDPI from Volume 12 Issue 3 (2020). Previous articles were published by another publisher in Open Access under a CC-BY licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Background:
Case Report

The Coexistence of Multiple Sclerosis and Hereditary Spastic Paraparesis in a Patient

by
Işıl Yazıcı
*,
Nılufer Yıldırım
and
Yaşar Zorlu
Department of Neurology, Izmır Tepecık Educatıonal and Research Hospıtal, Izmir, Turkey
*
Author to whom correspondence should be addressed.
Neurol. Int. 2013, 5(2), e6; https://doi.org/10.4081/ni.2013.e6
Submission received: 30 November 2012 / Revised: 22 January 2013 / Accepted: 26 February 2013 / Published: 25 June 2013

Abstract

Multiple sclerosis (MS) is a chronic disease characterized by multiple areas of central nervous system inflammation, demyelination and axonal loss. Hereditary spastic paraparesis (HSP) is characterized clinically by progressive spasticity and weakness of the lower limbs and pathologically by retrograd axonal degeneration of the corticospinal tracts and posterior columns. We identified a patient with clinical history and investigation findings consistent with the concurrence of both MS and HSP. Laboratory and radiological investigations, cognitive tests were performed. Genetic confirmation for spastin gene mutation has been completed. If this coexistence is not coincidence the mutation in the spastin gene may be a strong susceptibility locus for MS.
Keywords: multiple sclerosis; spastin; hereditary spastic paraparesis multiple sclerosis; spastin; hereditary spastic paraparesis

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MDPI and ACS Style

Yazıcı, I.; Yıldırım, N.; Zorlu, Y. The Coexistence of Multiple Sclerosis and Hereditary Spastic Paraparesis in a Patient. Neurol. Int. 2013, 5, e6. https://doi.org/10.4081/ni.2013.e6

AMA Style

Yazıcı I, Yıldırım N, Zorlu Y. The Coexistence of Multiple Sclerosis and Hereditary Spastic Paraparesis in a Patient. Neurology International. 2013; 5(2):e6. https://doi.org/10.4081/ni.2013.e6

Chicago/Turabian Style

Yazıcı, Işıl, Nılufer Yıldırım, and Yaşar Zorlu. 2013. "The Coexistence of Multiple Sclerosis and Hereditary Spastic Paraparesis in a Patient" Neurology International 5, no. 2: e6. https://doi.org/10.4081/ni.2013.e6

APA Style

Yazıcı, I., Yıldırım, N., & Zorlu, Y. (2013). The Coexistence of Multiple Sclerosis and Hereditary Spastic Paraparesis in a Patient. Neurology International, 5(2), e6. https://doi.org/10.4081/ni.2013.e6

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