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Neurology International, Volume 17, Issue 3

March 2025 - 14 articles

Cover Story: Cerebral vasospasm (CVS) and delayed cerebral ischemia (DCI) remain significant causes of morbidity and mortality following aneurysmal subarachnoid hemorrhage (aSAH). Current strategies, including nimodipine and endovascular interventions, have limitations in preventing or treating established CVS. Milrinone, a phosphodiesterase-3 inhibitor, has shown potential in enhancing cerebral perfusion and reducing ischemic injury. This review consolidates the available evidence, examines milrinone’s pharmacodynamics, and proposes an evidence-based treatment algorithm. While promising, these therapeutic strategies require further validation to increase the level of evidence for standardizing their integration into neurocritical care protocols. With this article, we attempt to summarize the relevant literature and establish a basis for the creation of a research protocol. View this paper

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Articles (14)

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Article

1,039 Views

16 Pages

Shifting Outcomes: Superior Functional Recovery in Embolic Stroke of Undetermined Source Compared to Cardioembolic Stroke

Jessica Seetge,
Balázs Cséke,
Zsófia Nozomi Karádi,
Edit Bosnyák and
László Szapáry

Neurol. Int.2025, 17(3), 35;https://doi.org/10.3390/neurolint17030035

25 February 2025

Background/Objectives: An embolic stroke of undetermined source (ESUS) is a subtype of ischemic stroke characterized by a non-lacunar infarct in the absence of a clearly identifiable embolic source, despite comprehensive diagnostic evaluation. While...

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Article

2,096 Views

14 Pages

Ultrasound-Guided Percutaneous Nerve Stimulation in Post-Stroke Spasticity: A Case Report

Francesco Sartori,
Albert Puig-Diví and
Javier Picañol

Neurol. Int.2025, 17(3), 34;https://doi.org/10.3390/neurolint17030034

24 February 2025

Introduction: Post-stroke spasticity (PSS) significantly impacts the quality of life for stroke survivors. While various treatments exist, options for refractory cases are limited. Ultrasound-guided percutaneous peripheral nerve stimulation (pPNS), c...

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Article

2,494 Views

19 Pages

Tracking Migraine Symptoms: A Longitudinal Comparison of Smartphone-Based Headache Diaries and Clinical Interviews

Nicolas Vandenbussche,
Jonas Van Der Donckt,
Mathias De Brouwer,
Bram Steenwinckel,
Marija Stojchevska,
Femke Ongenae,
Sofie Van Hoecke and
Koen Paemeleire

Neurol. Int.2025, 17(3), 33;https://doi.org/10.3390/neurolint17030033

24 February 2025

Background/Objectives: By leveraging the capabilities of a smartphone-based headache diary, the objective of this study was to determine the amount of agreement between migraine-associated symptomatology during headache events and the symptoms docume...

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Review

1 Citations

8,745 Views

20 Pages

Evidence-Based Approach to Cerebral Vasospasm and Delayed Cerebral Ischemia: Milrinone as a Therapeutic Option—A Narrative Literature Review and Algorithm Treatment Proposition

Pedro Batarda Sena,
Marta Gonçalves,
Bruno Maia,
Margarida Fernandes and
Luís Bento

Neurol. Int.2025, 17(3), 32;https://doi.org/10.3390/neurolint17030032

21 February 2025

Aneurysmal subarachnoid hemorrhage (aSAH) is a severe neurocritical condition often complicated by cerebral vasospasm (CVS), leading to delayed cerebral ischemia (DCI) and significant morbidity and mortality. Despite advancements in management, thera...

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Neurol. Int. - ISSN 2035-8377

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