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Neurology International, Volume 17, Issue 3

March 2025 - 14 articles

Cover Story: Cerebral vasospasm (CVS) and delayed cerebral ischemia (DCI) remain significant causes of morbidity and mortality following aneurysmal subarachnoid hemorrhage (aSAH). Current strategies, including nimodipine and endovascular interventions, have limitations in preventing or treating established CVS. Milrinone, a phosphodiesterase-3 inhibitor, has shown potential in enhancing cerebral perfusion and reducing ischemic injury. This review consolidates the available evidence, examines milrinone’s pharmacodynamics, and proposes an evidence-based treatment algorithm. While promising, these therapeutic strategies require further validation to increase the level of evidence for standardizing their integration into neurocritical care protocols. With this article, we attempt to summarize the relevant literature and establish a basis for the creation of a research protocol. View this paper
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Articles (14)

  • Review
  • Open Access
6 Citations
3,940 Views
21 Pages

Artificial Intelligence in the Diagnosis of Neurological Diseases Using Biomechanical and Gait Analysis Data: A Scopus-Based Bibliometric Analysis

  • Aikaterini A. Tsiara,
  • Spyridon Plakias,
  • Christos Kokkotis,
  • Aikaterini Veneri,
  • Minas A. Mina,
  • Anna Tsiakiri,
  • Sofia Kitmeridou,
  • Foteini Christidi,
  • Evangelos Gourgoulis and
  • Triantafylos Doskas
  • + 4 authors

Neurological diseases are increasingly diverse and prevalent, presenting significant challenges for their timely and accurate diagnosis. The aim of the present study is to conduct a bibliometric analysis and literature review in the field of neurolog...

  • Article
  • Open Access
980 Views
12 Pages

Background/Objectives: Responsiveness and minimal important change (MIC) are key metrics that vary across conditions and should be determined for specific populations. However, these metrics have not yet been established for the Mini-Balance Evaluati...

  • Case Report
  • Open Access
1 Citations
1,451 Views
7 Pages

Background: Pediatric optic neuritis (ON) is a rare but severe condition characterized by acute visual impairment, with 3–5% of relapsing cases lacking identifiable markers for associated conditions, such as neuromyelitis optica spectrum disord...

  • Article
  • Open Access
3 Citations
1,880 Views
13 Pages

Dysregulation of Retinal Melatonin Biosynthetic Pathway and Differential Expression of Retina-Specific Genes Following Blast-Induced Ocular Injury in Ferrets

  • Chetan Pundkar,
  • Rex Jeya Rajkumar Samdavid Thanapaul,
  • Manoj Govindarajulu,
  • Gaurav Phuyal,
  • Joseph B. Long and
  • Peethambaran Arun

Background/Objectives: Blast-induced traumatic ocular injuries (bTOI) pose a significant risk to military and civilian populations, often leading to visual impairment or blindness. Retina, the innermost layer of ocular tissue consisting of photorecep...

  • Review
  • Open Access
4 Citations
2,939 Views
41 Pages

Glial Cells in Spinal Muscular Atrophy: Speculations on Non-Cell-Autonomous Mechanisms and Therapeutic Implications

  • Andrej Belančić,
  • Tamara Janković,
  • Elvira Meni Maria Gkrinia,
  • Iva Kristić,
  • Jelena Rajič Bumber,
  • Valentino Rački,
  • Kristina Pilipović,
  • Dinko Vitezić and
  • Jasenka Mršić-Pelčić

Spinal muscular atrophy (SMA) is a neuromuscular disorder caused by homozygous deletions or mutations in the SMN1 gene, leading to progressive motor neuron degeneration. While SMA has been classically viewed as a motor neuron-autonomous disease, incr...

  • Article
  • Open Access
3,218 Views
13 Pages

The Impact of Biseasonal Time Changes on Migraine

  • Carl H. Göbel,
  • Katja Heinze-Kuhn,
  • Axel Heinze,
  • Anna Cirkel and
  • Hartmut Göbel

Background: Changes in the daily rhythm can trigger migraine attacks. The sensitivity for triggering attacks is closely linked to the regulation of biological rhythms controlled by the hypothalamus. In over 70 countries around the world, the time is...

  • Article
  • Open Access
1 Citations
1,916 Views
12 Pages

The Impact of Age on Outcomes in Seizure Hospitalizations—Analysis of a National Sample

  • Anudeep Surendranath,
  • Saurabh Singhal,
  • Rahul Khanna,
  • Subhendu Rath and
  • Temenuzhka Mihaylova

Objective: Seizures are a critical public health issue, with incidence rising significantly after age 50. Using this inflection point, we divided patients into two age groups to examine the impact of age on patient characteristics and hospitalization...

  • Article
  • Open Access
3 Citations
1,831 Views
16 Pages

Using Immunoliposomes as Carriers to Enhance the Therapeutic Effectiveness of Macamide N-3-Methoxybenzyl-Linoleamide

  • Karin J. Vera-López,
  • María Aranzamendi-Zenteno,
  • Gonzalo Davila-Del-Carpio and
  • Rita Nieto-Montesinos

Background/Objectives: Epilepsy is one of the most common chronic neurological disorders, characterized by alterations in neuronal electrical activity that result in recurrent seizures and involuntary body movements. Anticonvulsants are the primary t...

  • Case Report
  • Open Access
1,523 Views
10 Pages

Confusing Onset of MOGAD in the Form of Focal Seizures

  • Małgorzata Jączak-Goździak and
  • Barbara Steinborn

MOGAD is a demyelinating syndrome with the presence of antibodies against myelin oligodendrocyte glycoprotein, which is, next to multiple sclerosis and the neuromyelitis optica spectrum, one of the manifestations of the demyelinating process, more co...

  • Review
  • Open Access
2 Citations
7,804 Views
17 Pages

The diagnosis of aneurysmal subarachnoid hemorrhage (aSAH) is most difficult in patients who are in good clinical condition with a small hemorrhage, especially when a ruptured aneurysm might not be considered, or if a computed tomographic (CT) scan i...

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Neurol. Int. - ISSN 2035-8377