Self-Assembled Nanoparticles of Silicon (IV)–NO Donor Phthalocyanine Conjugate for Tumor Photodynamic Therapy in Red Light

Aikelamu, Kadireya; Bai, Jingya; Zhang, Qian; Huang, Jiamin; Wang, Mei; Zhong, Chunhong

doi:10.3390/pharmaceutics16091166

Open AccessArticle

Self-Assembled Nanoparticles of Silicon (IV)–NO Donor Phthalocyanine Conjugate for Tumor Photodynamic Therapy in Red Light

by

Kadireya Aikelamu

,

Jingya Bai

,

Qian Zhang

,

Jiamin Huang

,

Mei Wang

^* and

Chunhong Zhong

^*

Xinjiang Key Laboratory of Natural Medicines Active Components and Drug Release Technology, Ministry of Education, Engineering Research Center of Xinjiang and Central Asian Medicine Resources, College of Pharmacy, Xinjiang Medical University, Urumqi 830017, China

^*

Authors to whom correspondence should be addressed.

Pharmaceutics 2024, 16(9), 1166; https://doi.org/10.3390/pharmaceutics16091166

Submission received: 23 July 2024 / Revised: 17 August 2024 / Accepted: 23 August 2024 / Published: 4 September 2024

(This article belongs to the Section Drug Targeting and Design)

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Abstract

The combination of photodynamic therapy (PDT) and pneumatotherapy is emerging as one of the most effective strategies for increasing cancer treatment efficacy while minimizing side effects. Photodynamic forces affect nitric oxide (NO) levels as activated photosensitizers produce NO, and NO levels in the tumor and microenvironment directly impact tumor cell responsiveness to PDT. In this paper, 3-benzenesulfonyl-4-(1-hydroxy ether)-1,2,5-oxadiazole-2-oxide NO donor–silicon phthalocyanine coupling (SiPc–NO) was designed and prepared into self-assembled nanoparticles (SiPc–NO@NPs) by precipitation method. By further introducing arginyl-glycyl-aspartic acid (RGD) on the surface of nanoparticles, NO-photosensitizer delivery systems (SiPc–NO@RGD NPs) with photo-responsive and tumor-targeting properties were finally prepared and preliminarily evaluated in terms of their formulation properties, NO release, and photosensitizing effects. Furthermore, high reactive oxygen species (ROS) generation efficiency and high PDT efficiency in two breast cancer cell lines (human MCF-7 and mouse 4T1) under irradiation were also demonstrated. The novel SiPc–NO@RGD NPs show great potential for application in NO delivery and two-photon bioimaging-guided photodynamic tumor therapy.

Keywords: nitric oxide; photosensitizer; self-assembled nanoparticles

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MDPI and ACS Style

Aikelamu, K.; Bai, J.; Zhang, Q.; Huang, J.; Wang, M.; Zhong, C. Self-Assembled Nanoparticles of Silicon (IV)–NO Donor Phthalocyanine Conjugate for Tumor Photodynamic Therapy in Red Light. Pharmaceutics 2024, 16, 1166. https://doi.org/10.3390/pharmaceutics16091166

AMA Style

Aikelamu K, Bai J, Zhang Q, Huang J, Wang M, Zhong C. Self-Assembled Nanoparticles of Silicon (IV)–NO Donor Phthalocyanine Conjugate for Tumor Photodynamic Therapy in Red Light. Pharmaceutics. 2024; 16(9):1166. https://doi.org/10.3390/pharmaceutics16091166

Chicago/Turabian Style

Aikelamu, Kadireya, Jingya Bai, Qian Zhang, Jiamin Huang, Mei Wang, and Chunhong Zhong. 2024. "Self-Assembled Nanoparticles of Silicon (IV)–NO Donor Phthalocyanine Conjugate for Tumor Photodynamic Therapy in Red Light" Pharmaceutics 16, no. 9: 1166. https://doi.org/10.3390/pharmaceutics16091166

APA Style

Aikelamu, K., Bai, J., Zhang, Q., Huang, J., Wang, M., & Zhong, C. (2024). Self-Assembled Nanoparticles of Silicon (IV)–NO Donor Phthalocyanine Conjugate for Tumor Photodynamic Therapy in Red Light. Pharmaceutics, 16(9), 1166. https://doi.org/10.3390/pharmaceutics16091166

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Self-Assembled Nanoparticles of Silicon (IV)–NO Donor Phthalocyanine Conjugate for Tumor Photodynamic Therapy in Red Light

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