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Pharmaceutics, Volume 16, Issue 10

October 2024 - 108 articles

Cover Story: Ensuring the prompt and effective induction of mucosal immune responses is a critical area of study in immunology. Nasal vaccines, in particular, offer a promising approach to disease prevention by targeting mucosal tissues. This review delves into the complexities of engineering nasal vaccines with different glycoconjugates aimed at engaging specific C-type lectin receptors, as well as their performance in the nasal mucosa. A thorough analysis of these formulations demonstrated consistent antigen uptake patterns, while further studies confirmed improved immune responses compared to conventional nasal delivery systems. These findings underline the efficacy-boosting potential of targeting CLRs in nasal vaccine development to strengthen immune protection, offering new strategies for more effectively combating respiratory pathogens. View this paper
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Articles (108)

  • Article
  • Open Access
1 Citations
1,845 Views
18 Pages

The Key Role of Wettability and Boundary Layer in Dissolution Rate Test

  • Alice Biasin,
  • Federico Pribac,
  • Erica Franceschinis,
  • Angelo Cortesi,
  • Lucia Grassi,
  • Dario Voinovich,
  • Italo Colombo,
  • Gabriele Grassi,
  • Gesmi Milcovich and
  • Mario Grassi
  • + 1 author

Background/Objectives: The present work proposes a mathematical model able to describe the dissolution of poly-disperse drug spherical particles in a solution (Dissolution Rate Test—DRT). DRT is a pivotal test performed in the pharmaceutical fi...

  • Article
  • Open Access
2,497 Views
14 Pages

Background/Objectives: Effective airway delivery of a fixed-dose combination of triple-aerosolized inhaled corticosteroid (ICS)/long-acting beta agonist (LABA)/long-acting muscarinic antagonist (LAMA) is likely to positively affect therapeutic respon...

  • Review
  • Open Access
43 Citations
9,879 Views
41 Pages

Innovations in Nanoemulsion Technology: Enhancing Drug Delivery for Oral, Parenteral, and Ophthalmic Applications

  • Shery Jacob,
  • Fathima Sheik Kather,
  • Sai H. S. Boddu,
  • Jigar Shah and
  • Anroop B. Nair

Nanoemulsions (NEs) are submicron-sized heterogeneous biphasic liquid systems stabilized by surfactants. They are physically transparent or translucent, optically isotropic, and kinetically stable, with droplet sizes ranging from 20 to 500 nm. Their...

  • Review
  • Open Access
61 Citations
12,358 Views
32 Pages

The remarkable versatility of gold nanoparticles (AuNPs) makes them innovative agents across various fields, including drug delivery, biosensing, catalysis, bioimaging, and vaccine development. This paper provides a detailed review of the important r...

  • Article
  • Open Access
7 Citations
3,824 Views
18 Pages

Antimicrobial Activities of Essential Oils of Different Pinus Species from Bosnia and Herzegovina

  • Snježana Mirković,
  • Vanja Tadić,
  • Marina T. Milenković,
  • Dušan Ušjak,
  • Gordana Racić,
  • Dragica Bojović and
  • Ana Žugić

Background/Objectives: The emergence of antimicrobial resistance has urged researchers to explore new antimicrobial agents, such as essential oils (EOs). The aim of this study was to examine chemical composition and antimicrobial activity of the EOs...

  • Article
  • Open Access
3 Citations
2,922 Views
19 Pages

Enhancing Gentamicin Antibacterial Activity by Co-Encapsulation with Thymoquinone in Liposomal Formulation

  • Raghad R. Alzahrani,
  • Manal M. Alkhulaifi,
  • Majed Al Jeraisy,
  • Abdulkareem M. Albekairy,
  • Rizwan Ali,
  • Bahauddeen M. Alrfaei,
  • Salleh N. Ehaideb,
  • Ahmed I. Al-Asmari,
  • Sultan Al Qahtani and
  • Abdulaziz Halwani
  • + 2 authors

Background and Purpose. Gentamicin (GEN) is a broad-spectrum antibiotic that cannot be prescribed freely because of its toxicity. Thymoquinone (THQ), a phytochemical, has antibacterial, antioxidant, and toxicity-reducing properties. However, its hydr...

  • Article
  • Open Access
2 Citations
1,990 Views
14 Pages

Prescribing Pattern and Safety Profile of Biological Agents for Psoriasis in Real-World Practice: A Four-Year Calabrian Pharmacovigilance Analysis

  • Caterina De Sarro,
  • Francesca Bosco,
  • Agnese Gagliardi,
  • Lorenza Guarnieri,
  • Stefano Ruga,
  • Antonio Fabiano,
  • Laura Costantino,
  • Antonio Leo,
  • Caterina Palleria and
  • Chiara Verduci
  • + 5 authors

Background: The treatment of psoriasis has made considerable progress with biologicals, including tumor necrosis factor inhibitors, and recently, monoclonal antibodies inhibiting directly interleukin (IL) 17, IL-23, or both IL-12/23. Newer biological...

  • Review
  • Open Access
157 Citations
40,438 Views
27 Pages

Artificial Intelligence (AI) Applications in Drug Discovery and Drug Delivery: Revolutionizing Personalized Medicine

  • Dolores R. Serrano,
  • Francis C. Luciano,
  • Brayan J. Anaya,
  • Baris Ongoren,
  • Aytug Kara,
  • Gracia Molina,
  • Bianca I. Ramirez,
  • Sergio A. Sánchez-Guirales,
  • Jesus A. Simon and
  • Greta Tomietto
  • + 5 authors

Artificial intelligence (AI) encompasses a broad spectrum of techniques that have been utilized by pharmaceutical companies for decades, including machine learning, deep learning, and other advanced computational methods. These innovations have unloc...

  • Article
  • Open Access
9 Citations
2,831 Views
19 Pages

Background: CPT is a pentacyclic monoterpene alkaloid with a wide spectrum of antitumor activity. Its clinical application is restricted due to poor water solubility, instability, and high toxicity. We developed a new kind of multifunctional micelles...

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Pharmaceutics - ISSN 1999-4923