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Pharmaceutics, Volume 15, Issue 10

October 2023 - 152 articles

Cover Story: The activation of adenosine receptors (ARs) after agonist binding induces specific signal transduction pathways depending on the AR subtype involved. The most expressed ARs in brain microvascular endothelial cells (ECs) are A1Rs and A2ARs. The activation of AR results in the activation of AC and RhoA-GTPase enzymes, which induces an increase in phosphorylated myosin light chain (MCL) and ezrin/radixin/moesin (ERM) proteins, causing the contraction of actomyosin and subsequent BBB disruption. Moreover, the activation of ARs induces a decrease in the expression of tight junction (TJ) proteins (claudin, occludin, ZO-1) and morphological changes in the actin cytoskeleton, inducing the disassembly of TJ proteins and alterations in blood–brain barrier (BBB) permeability. AR antagonists reverted the effects caused by AR activation. View this paper
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Articles (152)

  • Article
  • Open Access
3 Citations
2,847 Views
19 Pages

Self-double emulsifying drug delivery systems have the potential to enhance the intestinal permeability of drugs classified under the Biopharmaceutics Classification System (BCS) class III. One such example is the antiviral agent zanamivir, exhibitin...

  • Review
  • Open Access
9 Citations
6,754 Views
15 Pages

Molecular Insights to the Structure-Interaction Relationships of Human Proton-Coupled Oligopeptide Transporters (PepTs)

  • Yining Luo,
  • Jingchun Gao,
  • Xukai Jiang,
  • Ling Zhu,
  • Qi Tony Zhou,
  • Michael Murray,
  • Jian Li and
  • Fanfan Zhou

Human proton-coupled oligopeptide transporters (PepTs) are important membrane influx transporters that facilitate the cellular uptake of many drugs including ACE inhibitors and antibiotics. PepTs mediate the absorption of di- and tri-peptides from di...

  • Review
  • Open Access
12 Citations
4,921 Views
21 Pages

Recent developments in artificial nucleic acid and drug delivery systems present possibilities for the symbiotic engineering of therapeutic oligonucleotides, such as antisense oligonucleotides (ASOs) and small interfering ribonucleic acids (siRNAs)....

  • Review
  • Open Access
197 Citations
12,016 Views
31 Pages

Natural Polymer-Based Hydrogels: From Polymer to Biomedical Applications

  • Lingling Zhao,
  • Yifan Zhou,
  • Jiaying Zhang,
  • Hongze Liang,
  • Xianwu Chen and
  • Hui Tan

Hydrogels prepared from natural polymer have attracted extensive attention in biomedical fields such as drug delivery, wound healing, and regenerative medicine due to their good biocompatibility, degradability, and flexibility. This review outlines t...

  • Article
  • Open Access
1 Citations
2,230 Views
16 Pages

Computational Amendment of Parenteral In Situ Forming Particulates’ Characteristics: Design of Experiment and PBPK Physiological Modeling

  • Nada M. El Hoffy,
  • Ahmed S. Yacoub,
  • Amira M. Ghoneim,
  • Magdy Ibrahim,
  • Hussein O. Ammar and
  • Nermin Eissa

Lipid and/or polymer-based drug conjugates can potentially minimize side effects by increasing drug accumulation at target sites and thus augment patient compliance. Formulation factors can present a potent influence on the characteristics of the obt...

  • Article
  • Open Access
8 Citations
2,293 Views
23 Pages

Evaluation of Oromucosal Natural Gum-Based Emulgels as Novel Strategy for Photodynamic Therapy of Oral Premalignant Lesions

  • Emilia Szymańska,
  • Joanna Potaś,
  • Marcin Baranowski,
  • Robert Czarnomysy,
  • Magdalena Ewa Sulewska,
  • Anna Basa,
  • Małgorzata Pietruska,
  • Krzysztof Bielawski and
  • Katarzyna Winnicka

Photodynamic therapy (PDT) recently has been shown as a promising option in the treatment of premalignant lesions of the soft oral tissues. Effective delivery of photosensitizer is challenging due to poor drug adherence to the oromucosal epithelium....

  • Article
  • Open Access
1 Citations
1,688 Views
16 Pages

Resensitisation of Methicillin-Resistant Staphylococcus aureus to Conventional Antibiotics in the Presence of an Engineered Enzybiotic

  • Salim Manoharadas,
  • Basel F. Al-Rayes,
  • Mohammed Abdulaziz M. Almuzaini and
  • Yasser Muteq Almohammadi

Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most dreadful pathogens relevant in community and nosocomial-related infections around the world. Resensitising MRSA to antibiotics, once it became resistant, was a tough choice due to...

  • Article
  • Open Access
16 Citations
3,120 Views
21 Pages

Nanoemulsions as a Promising Carrier for Topical Delivery of Etodolac: Formulation Development and Characterization

  • Samet Özdemir,
  • Burcu Üner,
  • Alptuğ Karaküçük,
  • Burak Çelik,
  • Engin Sümer and
  • Çetin Taş

This research primarily focuses on the development of innovative topical nanoemulsions for etodolac, aimed at surmounting its inherent limitations. The preparation of etodolac nanoemulsions is accomplished through a combination of high shear homogeni...

  • Article
  • Open Access
31 Citations
3,583 Views
20 Pages

Study of Biological Behavior and Antimicrobial Properties of Cerium Oxide Nanoparticles

  • Iason Chatzimentor,
  • Ioannis Tsamesidis,
  • Maria-Eleni Ioannou,
  • Georgia K. Pouroutzidou,
  • Anastasia Beketova,
  • Veronica Giourieva,
  • Rigini Papi and
  • Eleana Kontonasaki

(1) Background: An element that has gained much attention in industrial and biomedical fields is Cerium (Ce). CeO2 nanoparticles have been proven to be promising regarding their different biomedical applications for the control of infection and infla...

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Pharmaceutics - ISSN 1999-4923