Special Issue "Pharmacokinetics of Nanomedicines"

Dear Colleagues,

As demonstrated by the recent progresses in vaccines and cancer therapy, nanomedicine could be viewed as a very promising strategy to significantly improve human health. The paradox is that the idea to use nanotechnology to enhance drug efficacy and tolerance was proposed more than 50 years ago; however, so few drug products have reached the market. One reason is that those drug delivery systems (DDS) are difficult to characterize and to produce at an industrial scale. One of the key features evaluated by drug agencies to approve new products is drug pharmacokinetics (i.e., absorption, distribution, metabolization and elimination of the drug from the body). Until very recently, the pharmacokinetics (PKs) of nanomedicines have been assessed using models initially designed for regular formulations. We now know that the fate of live organisms, of a nanoparticle encapsulating an active pharmaceutical ingredient (API), has to be studied with specific models since it is modified as soon as it comes into contact with living tissues or liquid. In order to help more DDS to reach the market and improve human health, the present Special Issue will gather the latest studies on this subject.

Prof. Dr. Frederic Lagarce
Guest Editor

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• nanomedicines
• drug delivery systems
• pharmacokinetics
• PKPD
• in vivo/in vitro models