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Article

Click-Chemistry Cross-Linking of Hyaluronan Graft Copolymers

1
Dipartimento di Biotecnologie, Chimica e Farmacia (Dipartimento di Eccellenza 2018–2022), Università degli Studi di Siena, Via Aldo Moro 2, 53100 Siena, Italy
2
Istituto di Scienze e Tecnologie Chimiche “G. Natta”-SCITEC (CNR), Via A. Corti 12, 20133 Milano, Italy
*
Authors to whom correspondence should be addressed.
Academic Editor: Thierry Vandamme
Pharmaceutics 2022, 14(5), 1041; https://doi.org/10.3390/pharmaceutics14051041
Received: 13 April 2022 / Revised: 4 May 2022 / Accepted: 7 May 2022 / Published: 11 May 2022
(This article belongs to the Special Issue Hydrogels in Pharmaceutical and Biomedical Applications)
An easy and viable crosslinking procedure by click-chemistry (click-crosslinking) of hyaluronic acid (HA) was developed. In particular, the clickable propargyl groups of hyaluronane-based HA-FA-Pg graft copolymers showing low and medium molecular weight values were exploited in crosslinking by click-chemistry by using a hexa(ethylene glycol) spacer. The resulting HA-FA-HEG-CL materials showed an apparent lack of in vitro cytotoxic effects, tuneable water affinity, and rheological properties according to the crosslinking degree that suggests their applicability in different biomedical fields. View Full-Text
Keywords: hyaluronic acid; ferulic acid; click-chemistry; crosslinking; hydrogel hyaluronic acid; ferulic acid; click-chemistry; crosslinking; hydrogel
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MDPI and ACS Style

Saletti, M.; Paolino, M.; Ballerini, L.; Giuliani, G.; Leone, G.; Lamponi, S.; Andreassi, M.; Bonechi, C.; Donati, A.; Piovani, D.; Schieroni, A.G.; Magnani, A.; Cappelli, A. Click-Chemistry Cross-Linking of Hyaluronan Graft Copolymers. Pharmaceutics 2022, 14, 1041. https://doi.org/10.3390/pharmaceutics14051041

AMA Style

Saletti M, Paolino M, Ballerini L, Giuliani G, Leone G, Lamponi S, Andreassi M, Bonechi C, Donati A, Piovani D, Schieroni AG, Magnani A, Cappelli A. Click-Chemistry Cross-Linking of Hyaluronan Graft Copolymers. Pharmaceutics. 2022; 14(5):1041. https://doi.org/10.3390/pharmaceutics14051041

Chicago/Turabian Style

Saletti, Mario, Marco Paolino, Lavinia Ballerini, Germano Giuliani, Gemma Leone, Stefania Lamponi, Marco Andreassi, Claudia Bonechi, Alessandro Donati, Daniele Piovani, Alberto G. Schieroni, Agnese Magnani, and Andrea Cappelli. 2022. "Click-Chemistry Cross-Linking of Hyaluronan Graft Copolymers" Pharmaceutics 14, no. 5: 1041. https://doi.org/10.3390/pharmaceutics14051041

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