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Volume 6
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Reply published on 12 September 2014, see Viruses 2014, 6(9), 3425-3427.
Comment of Viruses 2014, 6(2), 524-534.
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Comment

Comment on Jameson et al.: Prevalence of Antibodies against Hantaviruses in Serum and Saliva of Adults Living or Working on Farms in Yorkshire, United Kingdom

by
Jan Clement
1,*,
Paula McKenna
2,
Valentijn Vergote
1 and
Marc Van Ranst
1
1
National Reference Centre for Hantavirus Infections, Laboratory of Clinical Virology, University Hospitals Gasthuisberg, Leuven, 3000, Belgium
2
Janssen, Pharmaceutical Companies of Johnson & Johnson, Beerse, 2340, Belgium
*
Author to whom correspondence should be addressed.
Viruses 2014, 6(9), 3415-3424; https://doi.org/10.3390/v6093415
Submission received: 10 July 2014 / Revised: 25 August 2014 / Accepted: 26 August 2014 / Published: 12 September 2014
Versions Notes

Abstract

This British hantavirus IgG prevalence study, aimed at 119 asymptomatic farmers in England, and using indirect immunofluorescence assay (IFA) as screening technique, concluded that rat-transmitted Seoul virus (SEOV) might be the main suspect as hantaviral pathogen in the UK. Exactly the same conclusion, using the same IFA screening technique, resulted from a 1994 serosurvey in the same country, and in 627 clinical cases plus 100 healthy controls. SEOV-positive study subjects were also mainly farmers with heavy rat-exposure, but residing in Northern-Ireland, a region where all other known rodent reservoirs for pathogenic hantaviruses are known to be absent, except the wild rat. A rodent capture action in and around the farms of eight seropositives confirmed SEOV seropositivity in 21.6% of 51 rats. All SEOV seropositives were patients, hospitalized with an acute feverish condition, a majority of which having the clinical picture of hantavirus-induced nephropathy, known as hemorrhagic fever with renal syndrome (HFRS). Leptospirosis, often mimicking perfectly HFRS, was serologically excluded. Thus, SEOV was established as a human hantaviral pathogen in the UK and in Europe 20 years ago.
Keywords: Seoul virus (SEOV); hantavirus; wild rat; prevalence; risk factors; hemorrhagic fever with renal syndrome (HFRS); U.K.; Northern Ireland Seoul virus (SEOV); hantavirus; wild rat; prevalence; risk factors; hemorrhagic fever with renal syndrome (HFRS); U.K.; Northern Ireland

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MDPI and ACS Style

Clement, J.; McKenna, P.; Vergote, V.; Van Ranst, M. Comment on Jameson et al.: Prevalence of Antibodies against Hantaviruses in Serum and Saliva of Adults Living or Working on Farms in Yorkshire, United Kingdom. Viruses 2014, 6, 3415-3424. https://doi.org/10.3390/v6093415

AMA Style

Clement J, McKenna P, Vergote V, Van Ranst M. Comment on Jameson et al.: Prevalence of Antibodies against Hantaviruses in Serum and Saliva of Adults Living or Working on Farms in Yorkshire, United Kingdom. Viruses. 2014; 6(9):3415-3424. https://doi.org/10.3390/v6093415

Chicago/Turabian Style

Clement, Jan, Paula McKenna, Valentijn Vergote, and Marc Van Ranst. 2014. "Comment on Jameson et al.: Prevalence of Antibodies against Hantaviruses in Serum and Saliva of Adults Living or Working on Farms in Yorkshire, United Kingdom" Viruses 6, no. 9: 3415-3424. https://doi.org/10.3390/v6093415

APA Style

Clement, J., McKenna, P., Vergote, V., & Van Ranst, M. (2014). Comment on Jameson et al.: Prevalence of Antibodies against Hantaviruses in Serum and Saliva of Adults Living or Working on Farms in Yorkshire, United Kingdom. Viruses, 6(9), 3415-3424. https://doi.org/10.3390/v6093415

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