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Lessons in AIDS Vaccine Development Learned from Studies of Equine Infectious, Anemia Virus Infection and Immunity
Center for Vaccine Research, Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA 15261, USA
* Author to whom correspondence should be addressed.
Received: 21 October 2013; in revised form: 20 November 2013 / Accepted: 25 November 2013 / Published: 2 December 2013
Abstract: Equine infectious anemia (EIA), identified in 1843  as an infectious disease of horses and as a viral infection in 1904, remains a concern in veterinary medicine today. Equine infectious anemia virus (EIAV) has served as an animal model of HIV-1/AIDS research since the original identification of HIV. Similar to other lentiviruses, EIAV has a high propensity for genomic sequence and antigenic variation, principally in its envelope (Env) proteins. However, EIAV possesses a unique and dynamic disease presentation that has facilitated comprehensive analyses of the interactions between the evolving virus population, progressive host immune responses, and the definition of viral and host correlates of immune control and vaccine efficacy. Summarized here are key findings in EIAV that have provided important lessons toward understanding long term immune control of lentivirus infections and the parameters for development of an enduring broadly protective AIDS vaccine.
Keywords: EIAV; lentivirus; pathogenesis; envelope diversity; vaccine development; immune maturation
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Cite This Article
MDPI and ACS Style
Craigo, J.K.; Montelaro, R.C. Lessons in AIDS Vaccine Development Learned from Studies of Equine Infectious, Anemia Virus Infection and Immunity. Viruses 2013, 5, 2963-2976.
Craigo JK, Montelaro RC. Lessons in AIDS Vaccine Development Learned from Studies of Equine Infectious, Anemia Virus Infection and Immunity. Viruses. 2013; 5(12):2963-2976.
Craigo, Jodi K.; Montelaro, Ronald C. 2013. "Lessons in AIDS Vaccine Development Learned from Studies of Equine Infectious, Anemia Virus Infection and Immunity." Viruses 5, no. 12: 2963-2976.