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Viruses
Volume 17
Issue 7
10.3390/v17070925
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Article

Characterisation of Orthohantavirus Serotypes in Human Infections in Kazakhstan

by
Nur Tukhanova
1,2,
Anna Shin
3,
Abhishek Bakuli
4,
Lyazzat Yeraliyeva
5,
Nurbek Maikanov
6,
Guenter Froeschl
4,
Zauresh Zhumadilova
1,
Gulnara Tokmurziyeva
1,
Edith Wagner
7,
Sandra Essbauer
8 and
Lukas Peintner
9,*
1
M. Aikimbayev’s National Scientific Center of Especially Dangerous Infections, 050054 Almaty, Kazakhstan
2
Department of Infectious and Tropical Disease, S. Asfendiyarov Kazakh National Medical University, 050012 Almaty, Kazakhstan
3
Department of General Medical Practice, Al-Farabi Kazakh National University, 050040 Almaty, Kazakhstan
4
Division of Infectious Diseases and Tropical Medicine, University Hospital, Ludwig-Maximilians-University, 80802 Munich, Germany
5
National Scientific Center of Phthisiopulmonology, 050010 Almaty, Kazakhstan
6
Oral Antiplague Station, 090001 Oral, Kazakhstan
7
Institute of Medical Microbiology, Jena University Hospital, 07747 Jena, Germany
8
Department of Virology and Intracellular Agents, Bundeswehr Institute of Microbiology, 80937 Munich, Germany
9
Institute of Molecular Medicine and Cell Research, University of Freiburg, 79104 Freiburg im Breisgau, Germany
*
Author to whom correspondence should be addressed.
Viruses 2025, 17(7), 925; https://doi.org/10.3390/v17070925 (registering DOI)
Submission received: 9 May 2025 / Revised: 16 June 2025 / Accepted: 26 June 2025 / Published: 28 June 2025
(This article belongs to the Special Issue Hantavirus 2024)
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Abstract

Orthohantavirus infection is a zoonotic disease transmitted to humans through contact with infected rodents. In Eurasia, Old World Orthohantaviruses can cause haemorrhagic fever with renal syndrome (HFRS), while in the Americas, New World Orthohantaviruses are responsible for hantavirus cardiopulmonary syndrome (HCPS). In Kazakhstan, the first recorded cases of HFRS appeared in the West Kazakhstan region in 2000, which has since then been established as an endemic area due to the presence of stable rodent reservoirs and recurring human infections. Routine diagnosis of HFRS in this region relies primarily on immunoassays. To enhance diagnostic precision, we aimed to implement both serological and molecular methods on samples from suspected HFRS cases in the endemic West Kazakhstan region and non-endemic Almaty City. A total of 139 paired serum, saliva, and urine samples were analysed using IgM/IgG ELISA, immunoblot assays, and qPCR. Our findings confirm that suspected HFRS cases in West Kazakhstan are associated with the Puumala virus serotype.
Keywords: Kazakhstan; orthohantavirus; serology; human infections Kazakhstan; orthohantavirus; serology; human infections
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MDPI and ACS Style

Tukhanova, N.; Shin, A.; Bakuli, A.; Yeraliyeva, L.; Maikanov, N.; Froeschl, G.; Zhumadilova, Z.; Tokmurziyeva, G.; Wagner, E.; Essbauer, S.; et al. Characterisation of Orthohantavirus Serotypes in Human Infections in Kazakhstan. Viruses 2025, 17, 925. https://doi.org/10.3390/v17070925

AMA Style

Tukhanova N, Shin A, Bakuli A, Yeraliyeva L, Maikanov N, Froeschl G, Zhumadilova Z, Tokmurziyeva G, Wagner E, Essbauer S, et al. Characterisation of Orthohantavirus Serotypes in Human Infections in Kazakhstan. Viruses. 2025; 17(7):925. https://doi.org/10.3390/v17070925

Chicago/Turabian Style

Tukhanova, Nur, Anna Shin, Abhishek Bakuli, Lyazzat Yeraliyeva, Nurbek Maikanov, Guenter Froeschl, Zauresh Zhumadilova, Gulnara Tokmurziyeva, Edith Wagner, Sandra Essbauer, and et al. 2025. "Characterisation of Orthohantavirus Serotypes in Human Infections in Kazakhstan" Viruses 17, no. 7: 925. https://doi.org/10.3390/v17070925

APA Style

Tukhanova, N., Shin, A., Bakuli, A., Yeraliyeva, L., Maikanov, N., Froeschl, G., Zhumadilova, Z., Tokmurziyeva, G., Wagner, E., Essbauer, S., & Peintner, L. (2025). Characterisation of Orthohantavirus Serotypes in Human Infections in Kazakhstan. Viruses, 17(7), 925. https://doi.org/10.3390/v17070925

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