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Viruses, Volume 16, Issue 1

January 2024 - 166 articles

Cover Story: It has been reported that platelets interact with and endocytose different viruses. However, the importance of this to thrombosis is unclear. We used the EcoHIV model to probe the effects of viremia on mouse platelets. EcoHIV caused a viral infection with an active virus in the spleen and a humoral immune response. However, the circulating virus was cleared rapidly and was undetectable by Day 7. No effects on platelets were detected in vivo, using several activation metrics. To explain our results, we showed that mouse platelets did not express the receptor for EcoHIV, murine Cationic Amino acid Transporter 1 (mCAT-1). Further, we showed that previous studies showing platelet activation and thrombocytopenia were caused by impurities in the Polyethylene Glycol (PEG) that precipitated EcoHIV preparations. View this paper
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Articles (166)

  • Review
  • Open Access
6 Citations
3,953 Views
17 Pages

22 January 2024

Double-stranded RNA (dsRNA) molecules are mediators of RNA interference (RNAi) in eukaryotic cells. RNAi is a conserved mechanism of post-transcriptional silencing of genes cognate to the sequences of the applied dsRNA. RNAi-based therapeutics for th...

  • Article
  • Open Access
2 Citations
6,011 Views
19 Pages

The Inovirus Pf4 Triggers Antiviral Responses and Disrupts the Proliferation of Airway Basal Epithelial Cells

  • Medeea C. Popescu,
  • Naomi L. Haddock,
  • Elizabeth B. Burgener,
  • Laura S. Rojas-Hernandez,
  • Gernot Kaber,
  • Aviv Hargil,
  • Paul L. Bollyky and
  • Carlos E. Milla

22 January 2024

Background: The inovirus Pf4 is a lysogenic bacteriophage of Pseudomonas aeruginosa (Pa). People with Cystic Fibrosis (pwCF) experience chronic airway infection with Pa and a significant proportion have high numbers of Pf4 in their airway secretions....

  • Article
  • Open Access
3 Citations
2,053 Views
14 Pages

Detection, Characterization and Sequencing of BTV Serotypes Circulating in Cuba in 2022

  • Ana María Acevedo,
  • Lydie Postic,
  • Maray Curiel,
  • Mathilde Gondard,
  • Emmanuel Bréard,
  • Stéphan Zientara,
  • Fabien Vorimore,
  • Mai-Lan Tran,
  • Mathilde Turpaud and
  • Giovanni Savini
  • + 8 authors

22 January 2024

In Cuba, despite a high sero-prevalence of bluetongue virus (BTV), circulating serotypes remain unknown. The aim of this study was to identify circulating BTV serotypes in farms throughout the western region of Cuba. Blood samples were collected from...

  • Article
  • Open Access
3 Citations
3,104 Views
11 Pages

The Chinese Hamster Ovary Cell-Based H9 HA Subunit Avian Influenza Vaccine Provides Complete Protection against the H9N2 Virus Challenge in Chickens

  • Shunfan Zhu,
  • Zhenyu Nie,
  • Ying Che,
  • Jianhong Shu,
  • Sufang Wu,
  • Yulong He,
  • Youqiang Wu,
  • Hong Qian,
  • Huapeng Feng and
  • Qiang Zhang

22 January 2024

(1) Background: Avian influenza has attracted widespread attention because of its severe effect on the poultry industry and potential threat to human health. The H9N2 subtype of avian influenza viruses was the most prevalent in chickens, and there ar...

  • Article
  • Open Access
5 Citations
3,783 Views
12 Pages

Vaccine and Non-Vaccine HPV Types Presence in Adolescents with Vertically Acquired HIV Five Years Post Gardasil Quadrivalent Vaccination: The ZIMGARD Cohort

  • Alltalents T. Murahwa,
  • Tinashe Mudzviti,
  • Racheal S. Dube Mandishora,
  • Takudzwa Chatindo,
  • Peace Chanetsa,
  • Margaret Pascoe,
  • Tinei Shamu,
  • Wisdom Basera,
  • Ruedi Luethy and
  • Anna-Lise Williamson

22 January 2024

Background: Human papillomavirus (HPV) vaccination programs are a key intervention in protecting individuals against HPV-related disease. HIV1-infected individuals are at increased risk of HPV-associated cancers. This study was conducted to evaluate...

  • Review
  • Open Access
6 Citations
3,682 Views
15 Pages

SARS-CoV-2 ORF8 as a Modulator of Cytokine Induction: Evidence and Search for Molecular Mechanisms

  • Marília Inês Móvio,
  • Giovana Waner Carneiro de Almeida,
  • Isabella das Graças Lopes Martines,
  • Gilmara Barros de Lima,
  • Sergio Daishi Sasaki,
  • Alexandre Hiroaki Kihara,
  • Emma Poole,
  • Michael Nevels and
  • Maria Cristina Carlan da Silva

22 January 2024

Severe cases of SARS-CoV-2 infection are characterized by an immune response that leads to the overproduction of pro-inflammatory cytokines, resulting in lung damage, cardiovascular symptoms, hematologic symptoms, acute kidney injury and multiple org...

  • Review
  • Open Access
9 Citations
15,816 Views
10 Pages

Human Rabies Treatment—From Palliation to Promise

  • Marian Lacy,
  • Nonthapan Phasuk and
  • Stephen J. Scholand

22 January 2024

Rabies encephalitis has plagued humankind for thousands of years. In developed countries, access to preventive care, both pre-exposure and post-exposure, has significantly reduced the burden of suffering and disease. However, around the world, rabies...

  • Article
  • Open Access
6 Citations
3,096 Views
16 Pages

Genomic Expedition: Deciphering Human Adenovirus Strains from the 2023 Outbreak in West Bengal, India: Insights into Viral Evolution and Molecular Epidemiology

  • Ananya Chatterjee,
  • Uttaran Bhattacharjee,
  • Rudrak Gupta,
  • Ashis Debnath,
  • Agniva Majumdar,
  • Ritubrita Saha,
  • Mamta Chawla-Sarkar,
  • Alok Kumar Chakrabarti and
  • Shanta Dutta

21 January 2024

Understanding the genetic dynamics of circulating Human Adenovirus (HAdV) types is pivotal for effectively managing outbreaks and devising targeted interventions. During the West Bengal outbreak of 2022–2023, an investigation into the genetic charact...

  • Article
  • Open Access
9 Citations
3,628 Views
17 Pages

The Global Evolutionary History of Orf Virus in Sheep and Goats Revealed by Whole Genomes Data

  • Elisabetta Coradduzza,
  • Fabio Scarpa,
  • Angela Maria Rocchigiani,
  • Carla Cacciotto,
  • Giada Lostia,
  • Mariangela Stefania Fiori,
  • Yoel Rodriguez Valera,
  • Alessandra Mistral De Pascali,
  • Martina Brandolini and
  • Ilenia Azzena
  • + 8 authors

21 January 2024

Orf virus (ORFV) belongs to the genus Parapoxvirus (Poxviridae family). It is the causative agent of contagious ecthyma (CE) that is an economically detrimental disease affecting small ruminants globally. Contagious ecthyma outbreaks are usually repo...

  • Article
  • Open Access
15 Citations
4,594 Views
13 Pages

Molecular Survey on Porcine Parvoviruses (PPV1-7) and Their Association with Major Pathogens in Reproductive Failure Outbreaks in Northern Italy

  • Giulia Faustini,
  • Claudia Maria Tucciarone,
  • Giovanni Franzo,
  • Anna Donneschi,
  • Maria Beatrice Boniotti,
  • Giovanni Loris Alborali and
  • Michele Drigo

21 January 2024

Successful reproductive performance is key to farm competitiveness in the global marketplace. Porcine parvovirus 1 (PPV1) has been identified as a major cause of reproductive failure, and since 2001 new species of porcine parvoviruses, namely PPV2&nd...

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Viruses - ISSN 1999-4915Creative Common CC BY license