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Viruses, Volume 15, Issue 9

September 2023 - 192 articles

Cover Story: Suppression of the human cytomegalovirus (HCMV) major immediate early protein (MIEP), to restrict the viral lytic transcription programme, is a pre-requisite for latency and is driven by repressive epigenetic modifications at the MIEP during latent infection. We and others have observed that LUNA, a latency-associated viral gene, enhances latency-associated expression. Here, we show that in the absence of LUNA, the expression of multiple latency-associated transcripts is reduced during latent infection. We also show that LUNA interacts with the hematopoietic transcription factor GATA-2, which is known to bind to a number of latency-associated gene promoters. As such, LUNA plays a key role in efficient latency-associated viral gene expression and the carriage of viral genomes during latent carriage. View this paper
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Articles (192)

  • Article
  • Open Access
11 Citations
2,415 Views
15 Pages

20 September 2023

Variability has been one of the hallmarks of canine parvovirus type 2 (CPV-2) since its discovery, and several lineages and antigenic variants have emerged. Among these, a group of viruses commonly called Asian CPV-2c has recently been reported with...

  • Article
  • Open Access
6 Citations
3,054 Views
24 Pages

The Antiviral Factor SERINC5 Impairs the Expression of Non-Self-DNA

  • Yuhang Shi,
  • Sydney Simpson,
  • Shahad K. Ahmed,
  • Yuexuan Chen,
  • Aidin Tavakoli-Tameh,
  • Sanath Kumar Janaka,
  • David T. Evans and
  • Ruth Serra-Moreno

20 September 2023

SERINC5 is a restriction factor that becomes incorporated into nascent retroviral particles, impairing their ability to infect target cells. In turn, retroviruses have evolved countermeasures against SERINC5. For instance, the primate lentiviruses (H...

  • Review
  • Open Access
15 Citations
4,104 Views
11 Pages

Trends and Challenges in the Surveillance and Control of Avian Metapneumovirus

  • Gleidson Biasi Carvalho Salles,
  • Giulia Von Tönnemann Pilati,
  • Eduardo Correa Muniz,
  • Antonio Junior de Lima Neto,
  • Josias Rodrigo Vogt,
  • Mariane Dahmer,
  • Beatriz Pereira Savi,
  • Dayane Azevedo Padilha and
  • Gislaine Fongaro

20 September 2023

Among the respiratory pathogens of birds, the Avian Metapneumovirus (aMPV) is one of the most relevant, as it is responsible for causing infections of the upper respiratory tract and may induce respiratory syndromes. aMPV is capable of affecting the...

  • Review
  • Open Access
18 Citations
4,137 Views
24 Pages

Fitness Determinants of Influenza A Viruses

  • Emily Fate Griffin and
  • Stephen Mark Tompkins

20 September 2023

Influenza A (IAV) is a major human respiratory pathogen that causes illness, hospitalizations, and mortality annually worldwide. IAV is also a zoonotic pathogen with a multitude of hosts, allowing for interspecies transmission, reassortment events, a...

  • Systematic Review
  • Open Access
12 Citations
3,014 Views
16 Pages

The Association between CCL5/RANTES SNPs and Susceptibility to HIV-1 Infection: A Meta-Analysis

  • Marcos Jessé Abrahão Silva,
  • Rebecca Lobato Marinho,
  • Pabllo Antonny Silva dos Santos,
  • Carolynne Silva dos Santos,
  • Layana Rufino Ribeiro,
  • Yan Corrêa Rodrigues,
  • Karla Valéria Batista Lima and
  • Luana Nepomuceno Gondim Costa Lima

20 September 2023

Genetic polymorphisms in genes that encode natural ligands of CCR5 (the main human HIV coreceptor), such as CCL5/RANTES, can alter the levels of secretion of these peptides. This article sought to review the relationship between single nucleotide pol...

  • Brief Report
  • Open Access
1 Citations
2,841 Views
7 Pages

Successful Confirmation of Dual Genital Herpes Co-Infection with Herpes Simplex Virus 1 and Herpes Simplex Virus 2 Using Unbiased Metagenomic Next-Generation Sequencing

  • Chun Kiat Lee,
  • Sau Yoke Ng,
  • Chean Nee Chai,
  • Yu Feng Lim,
  • Tiffany Jingyan Hu,
  • Ogestelli Fabia Lee and
  • Gabriel Yan

20 September 2023

Dual co-infection with both HSV-1 and HSV-2 is rare, with few cases reported in the literature. In this case report, we describe the successful use of unbiased metagenomic next-generation sequencing (mNGS) as a rapid and alternative method for confir...

  • Article
  • Open Access
7 Citations
5,225 Views
27 Pages

The Influenza B Virus Victoria and Yamagata Lineages Display Distinct Cell Tropism and Infection-Induced Host Gene Expression in Human Nasal Epithelial Cell Cultures

  • Jo L. Wilson,
  • Elgin Akin,
  • Ruifeng Zhou,
  • Anne Jedlicka,
  • Amanda Dziedzic,
  • Hsuan Liu,
  • Katherine Z. J. Fenstermacher,
  • Richard E. Rothman and
  • Andrew Pekosz

20 September 2023

Understanding Influenza B virus infections is of critical importance in our efforts to control severe influenza and influenza-related diseases. Until 2020, two genetic lineages of influenza B virus—Yamagata and Victoria—circulated in the...

  • Article
  • Open Access
17 Citations
2,450 Views
15 Pages

Seasonal Occurrence of African Swine Fever in Wild Boar and Domestic Pigs in EU Member States

  • Lisa Rogoll,
  • Ann-Kathrin Güttner,
  • Katja Schulz,
  • Hannes Bergmann,
  • Christoph Staubach,
  • Franz J. Conraths and
  • Carola Sauter-Louis

20 September 2023

Since 2007, African swine fever (ASF) has spread widely within Europe and beyond. Most affected countries recorded outbreaks in domestic pigs and cases in wild boar. Outbreak data from 2014 to 2021 were used to investigate the seasonal pattern of ASF...

  • Review
  • Open Access
22 Citations
7,101 Views
20 Pages

When Bacteria and Viruses Collide: A Tale of Chlamydia trachomatis and Sexually Transmitted Viruses

  • Ehsan Ghasemian,
  • Emma Harding-Esch,
  • David Mabey and
  • Martin J. Holland

19 September 2023

The global incidence of sexually transmitted infections (STIs) remains high, with the World Health Organization (WHO) estimating that over 1 million people acquire STIs daily. STIs can lead to infertility, pregnancy complications, and cancers. Co-inf...

  • Article
  • Open Access
4 Citations
2,238 Views
12 Pages

The High-Risk Human Papillomavirus Type Influences the Tissue Microenvironment in Cervical Intraepithelial Neoplasia Grade 2

  • Mayumi Saito,
  • Aarthi Rajesh,
  • Carrie Innes,
  • Rachael van der Griend,
  • Peter Fitzgerald,
  • Bryony Simcock,
  • Peter Sykes and
  • Merilyn Hibma

19 September 2023

High-risk, cancer-causing human papillomavirus (HPV) types are associated with cervical precancer and cancer. A high proportion of high-risk HPV precancer lesions undergo immune-mediated regression. The purpose of this study was to determine if the t...

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Viruses - ISSN 1999-4915