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Article

Antiviral Activity of Umifenovir In Vitro against a Broad Spectrum of Coronaviruses, Including the Novel SARS-CoV-2 Virus

1
Mechnikov Research Institute of Vaccines and Sera, 105064 Moscow, Russia
2
Smorodintsev Research Institute of Influenza, 197376 Saint-Petersburg, Russia
3
International Biotechnology Center IBC “GENERIUM”, Volginsky Village, Petushinsky District, 601125 Vladimir, Russia
*
Author to whom correspondence should be addressed.
Academic Editors: Larisa Rudenko and Irina Isakova-Sivak
Viruses 2021, 13(8), 1665; https://doi.org/10.3390/v13081665
Received: 30 June 2021 / Revised: 12 August 2021 / Accepted: 18 August 2021 / Published: 23 August 2021
(This article belongs to the Special Issue State-of-the-Art Respiratory Viruses Research in Russia)
An escalating pandemic of the novel SARS-CoV-2 virus is impacting global health, and effective antivirals are needed. Umifenovir (Arbidol) is an indole-derivative molecule, licensed in Russia and China for prophylaxis and treatment of influenza and other respiratory viral infections. It has been shown that umifenovir has broad spectrum activity against different viruses. We evaluated the sensitivity of different coronaviruses, including the novel SARS-CoV-2 virus, to umifenovir using in vitro assays. Using a plaque assay, we revealed an antiviral effect of umifenovir against seasonal HCoV-229E and HCoV-OC43 coronaviruses in Vero E6 cells, with estimated 50% effective concentrations (EC50) of 10.0 ± 0.5 µM and 9.0 ± 0.4 µM, respectively. Umifenovir at 90 µM significantly suppressed plaque formation in CMK-AH-1 cells infected with SARS-CoV. Umifenovir also inhibited the replication of SARS-CoV-2 virus, with EC50 values ranging from 15.37 ± 3.6 to 28.0 ± 1.0 µM. In addition, 21–36 µM of umifenovir significantly suppressed SARS-CoV-2 virus titers (≥2 log TCID50/mL) in the first 24 h after infection. Repurposing of antiviral drugs is very helpful in fighting COVID-19. A safe, pan-antiviral drug such as umifenovir could be extremely beneficial in combating the early stages of a viral pandemic. View Full-Text
Keywords: coronaviruses; SARS-CoV; SARS-CoV-2; umifenovir; antiviral activity coronaviruses; SARS-CoV; SARS-CoV-2; umifenovir; antiviral activity
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MDPI and ACS Style

Leneva, I.; Kartashova, N.; Poromov, A.; Gracheva, A.; Korchevaya, E.; Glubokova, E.; Borisova, O.; Shtro, A.; Loginova, S.; Shchukina, V.; Khamitov, R.; Faizuloev, E. Antiviral Activity of Umifenovir In Vitro against a Broad Spectrum of Coronaviruses, Including the Novel SARS-CoV-2 Virus. Viruses 2021, 13, 1665. https://doi.org/10.3390/v13081665

AMA Style

Leneva I, Kartashova N, Poromov A, Gracheva A, Korchevaya E, Glubokova E, Borisova O, Shtro A, Loginova S, Shchukina V, Khamitov R, Faizuloev E. Antiviral Activity of Umifenovir In Vitro against a Broad Spectrum of Coronaviruses, Including the Novel SARS-CoV-2 Virus. Viruses. 2021; 13(8):1665. https://doi.org/10.3390/v13081665

Chicago/Turabian Style

Leneva, Irina, Nadezhda Kartashova, Artem Poromov, Anastasiia Gracheva, Ekaterina Korchevaya, Ekaterina Glubokova, Olga Borisova, Anna Shtro, Svetlana Loginova, Veronika Shchukina, Ravil Khamitov, and Evgeny Faizuloev. 2021. "Antiviral Activity of Umifenovir In Vitro against a Broad Spectrum of Coronaviruses, Including the Novel SARS-CoV-2 Virus" Viruses 13, no. 8: 1665. https://doi.org/10.3390/v13081665

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