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Viruses 2018, 10(5), 261; https://doi.org/10.3390/v10050261

Properties and Functions of Feline Immunodeficiency Virus Gag Domains in Virion Assembly and Budding

Laboratorio de Virología, CONICET-Universidad de Belgrano, Villanueva 1324, Buenos Aires C1426BMJ, Argentina
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Received: 5 April 2018 / Revised: 13 May 2018 / Accepted: 14 May 2018 / Published: 16 May 2018
(This article belongs to the Special Issue Nonprimate Lentivirus)
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Abstract

Feline immunodeficiency virus (FIV) is an important cat pathogen worldwide whose biological and pathophysiological properties resemble those of human immunodeficiency virus type 1 (HIV-1). Therefore, the study of FIV not only benefits its natural host but is also useful for the development of antiviral strategies directed against HIV-1 infections in humans. FIV assembly results from the multimerization of a single but complex viral polypeptide, the Gag precursor. In this review, we will first give an overview of the current knowledge of the proteins encoded by the FIV pol, env, rev, vif, and orf-A genes, and then we will describe and discuss in detail the critical roles that each of the FIV Gag domains plays in virion morphogenesis. Since retroviral assembly is an attractive target for therapeutic interventions, gaining a better understanding of this process is highly desirable. View Full-Text
Keywords: feline immunodeficiency virus; Gag polyprotein; retrovirus assembly; retrovirus budding feline immunodeficiency virus; Gag polyprotein; retrovirus assembly; retrovirus budding
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González, S.A.; Affranchino, J.L. Properties and Functions of Feline Immunodeficiency Virus Gag Domains in Virion Assembly and Budding. Viruses 2018, 10, 261.

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