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Preparation of Layer-by-Layer Films Composed of Polysaccharides and Poly(Amidoamine) Dendrimer Bearing Phenylboronic Acid and Their pH- and Sugar-Dependent Stability

1
School of Pharmaceutical Sciences, Ohu University, 31-1 Misumido, Tomita-machi, Koriyama, Fukushima 963-8611, Japan
2
Graduate School of Pharmaceutical Sciences, Tohoku University, Aramaki, Aoba-ku, Sendai 980-8578, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Andrew J. Ruys
Materials 2016, 9(6), 425; https://doi.org/10.3390/ma9060425
Received: 21 April 2016 / Revised: 6 May 2016 / Accepted: 25 May 2016 / Published: 28 May 2016
(This article belongs to the Section Biomaterials)
Layer-by-layer films composed of polysaccharides and poly(amidoamine) dendrimer bearing phenylboronic acid (PBA-PAMAM) were prepared to study the deposition behavior of the films and their stability in buffer solutions and in sugar solutions. Alginic acid (AGA) and carboxymethylcellulose (CMC) were employed as counter-polymers in constructing LbL films. AGA/PBA-PAMAM films were successfully prepared at pH 6.0–9.0, whereas the preparation of CMC/PBA-PAMAM film was unsuccessful at pH 8.0 and 9.0. The results show that the LbL films formed mainly through electrostatic affinity between PBA-PAMAM and polysaccharides, while, for AGA/PBA-PAMAM films, the participation of boronate ester bonds in the films was suggested. AGA/PBA-PAMAM films were stable in the solutions of pH 6.0–9.0. In contrast, CMC/PBA-PAMAM films decomposed at pH 7.5–9.0. The AGA/PBA-PAMAM films decomposed in response to 5–30 mM fructose at pH 7.5, while the films were stable in glucose solutions. Thus, AGA is useful as a counter-polymer for constructing PBA-PAMAM films that are stable at physiological pH and decompose in response to fructose. View Full-Text
Keywords: layer-by-layer film; pH-sensitive; sugar-sensitive; dendrimer; phenylboronic acid; polysaccharide; alginic acid; carboxymethylcellulose layer-by-layer film; pH-sensitive; sugar-sensitive; dendrimer; phenylboronic acid; polysaccharide; alginic acid; carboxymethylcellulose
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MDPI and ACS Style

Yoshida, K.; Suwa, K.; Anzai, J.-I. Preparation of Layer-by-Layer Films Composed of Polysaccharides and Poly(Amidoamine) Dendrimer Bearing Phenylboronic Acid and Their pH- and Sugar-Dependent Stability. Materials 2016, 9, 425.

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