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Open AccessReview

Bone Regeneration Using Bone Morphogenetic Proteins and Various Biomaterial Carriers

Faculty of Dentistry, University of Toronto, 150 College Street, Toronto, ON M5S 3E2, Canada
Division of Periodontics, Faculty of Dentistry, the Nobel Biocare Oral Health Centre, the University of British Columbia, 2151 Wesbrook Mall, Vancouver, BC V6T 1Z3, Canada
Division of Periodontics, Dental Diagnostic and Surgical Sciences, Faculty of Dentistry, University of Manitoba, D343-790 Bannatyne Avenue, Winnipeg, MB R3E 0W2, Canada
Department of Emergency and Trauma, South City Hospital, Street 1, Block 3, Sharah-e-Firdous, Clifton Karachi 75400, Pakistan
Author to whom correspondence should be addressed.
Academic Editor: Ihtesham ur Rehman
Materials 2015, 8(4), 1778-1816;
Received: 20 January 2015 / Revised: 24 March 2015 / Accepted: 27 March 2015 / Published: 15 April 2015
(This article belongs to the Special Issue Dental Materials)
PDF [871 KB, uploaded 15 April 2015]


Trauma and disease frequently result in fractures or critical sized bone defects and their management at times necessitates bone grafting. The process of bone healing or regeneration involves intricate network of molecules including bone morphogenetic proteins (BMPs). BMPs belong to a larger superfamily of proteins and are very promising and intensively studied for in the enhancement of bone healing. More than 20 types of BMPs have been identified but only a subset of BMPs can induce de novo bone formation. Many research groups have shown that BMPs can induce differentiation of mesenchymal stem cells and stem cells into osteogenic cells which are capable of producing bone. This review introduces BMPs and discusses current advances in preclinical and clinical application of utilizing various biomaterial carriers for local delivery of BMPs to enhance bone regeneration. View Full-Text
Keywords: bone morphogenetic proteins; BMPs; bone regeneration; biomaterials; carrier methods bone morphogenetic proteins; BMPs; bone regeneration; biomaterials; carrier methods
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Sheikh, Z.; Javaid, M.A.; Hamdan, N.; Hashmi, R. Bone Regeneration Using Bone Morphogenetic Proteins and Various Biomaterial Carriers. Materials 2015, 8, 1778-1816.

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