Novel Textile Scaffolds Generated by Flock Technology for Tissue Engineering of Bone and Cartilage
by
Anja Walther 1,2, Birgit Hoyer 2, Armin Springer 2, Birgit Mrozik 3, Thomas Hanke 1, Chokri Cherif 4, Wolfgang Pompe 1 and Michael Gelinsky 2,*
Anja Walther 1,2, Birgit Hoyer 2, Armin Springer 2, Birgit Mrozik 3, Thomas Hanke 1, Chokri Cherif 4, Wolfgang Pompe 1 and Michael Gelinsky 2,*
1
Max Bergmann Center of Biomaterials, Institute for Materials Science, Technische Universität Dresden, Budapester Str. 27, Dresden 01069, Germany
2
Centre for Translational Bone, Joint and Soft Tissue Research, Medical Faculty of Technische Universität Dresden, University Hospital Carl Gustav Carus, Fetscherstr. 74, Dresden 01307, Germany
3
Ingenieurbüro, Voglerstr. 33, Dresden 01277, Germany
4
Institute of Textile Machinery and High Performance Material Technology, Technische Universität Dresden, Dresden 01062, Germany
*
Author to whom correspondence should be addressed.
Materials 2012, 5(3), 540-557; https://doi.org/10.3390/ma5030540
Received: 22 December 2011 / Revised: 7 March 2012 / Accepted: 12 March 2012 / Published: 22 March 2012
(This article belongs to the Special Issue Fibrous Scaffolds for Tissue Engineering)
Textile scaffolds can be found in a variety of application areas in regenerative medicine and tissue engineering. In the present study we used electrostatic flocking—a well-known textile technology—to produce scaffolds for tissue engineering of bone. Flock scaffolds stand out due to their unique structure: parallel arranged fibers that are aligned perpendicularly to a substrate, resulting in mechanically stable structures with a high porosity. In compression tests we demonstrated good mechanical properties of such scaffolds and in cell culture experiments we showed that flock scaffolds allow attachment and proliferation of human mesenchymal stem cells and support their osteogenic differentiation. These matrices represent promising scaffolds for tissue engineering.
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Keywords:
tissue engineering; flock scaffold; flock technology; bone; cartilage
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MDPI and ACS Style
Walther, A.; Hoyer, B.; Springer, A.; Mrozik, B.; Hanke, T.; Cherif, C.; Pompe, W.; Gelinsky, M. Novel Textile Scaffolds Generated by Flock Technology for Tissue Engineering of Bone and Cartilage. Materials 2012, 5, 540-557.
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