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Volume 14
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10.3390/ma14226915
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Article

A Novel Biodegradable Composite Polymer Material Based on PLGA and Silver Oxide Nanoparticles with Unique Physicochemical Properties and Biocompatibility with Mammalian Cells

by
Veronika V. Smirnova
1,
Denis N. Chausov
1,
Dmitriy A. Serov
1,
Valery A. Kozlov
1,2,
Petr I. Ivashkin
1,
Roman Y. Pishchalnikov
1,
Oleg V. Uvarov
1,
Maria V. Vedunova
1,3,
Anastasia A. Semenova
4,
Andrey B. Lisitsyn
4 and
Alexander V. Simakin
1,*
1
Prokhorov General Physics Institute of the Russian Academy of Sciences, Vavilova Str. 38, 119991 Moscow, Russia
2
Department of Fundamental Science, Bauman Moscow State Technical University, 2-nd Baumanskaya Str. 5, 105005 Moscow, Russia
3
Institute of Biology and Biomedicine, Lobachevsky State, University of Nizhni Novgorod, 23 Gagarin Ave., 603950 Nizhny Novgorod, Russia
4
V. M. Gorbatov Federal Research Center for Food Systems of the Russian Academy of Sciences, 109316 Moscow, Russia
*
Author to whom correspondence should be addressed.
Materials 2021, 14(22), 6915; https://doi.org/10.3390/ma14226915
Submission received: 25 October 2021 / Revised: 11 November 2021 / Accepted: 13 November 2021 / Published: 16 November 2021
(This article belongs to the Special Issue Leveraging Advancements in Nanomaterials: Metrology, Synthesis and Properties for Biomedical Applications)
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Abstract

A method for obtaining a stable colloidal solution of silver oxide nanoparticles has been developed using laser ablation. The method allows one to obtain nanoparticles with a monomodal size distribution and a concentration of more than 108 nanoparticles per mL. On the basis of the obtained nanoparticles and the PLGA polymer, a nanocomposite material was manufactured. The manufacturing technology allows one to obtain a nanocomposite material without significant defects. Nanoparticles are not evenly distributed in the material and form domains in the composite. Reactive oxygen species (hydrogen peroxide and hydroxyl radical) are intensively generated on the surfaces of the nanocomposite. Additionally, on the surface of the composite material, an intensive formation of protein long-lived active forms is observed. The ELISA method was used to demonstrate the generation of 8-oxoguanine in DNA on the developed nanocomposite material. It was found that the multiplication of microorganisms on the developed nanocomposite material is significantly decreased. At the same time, the nanocomposite does not inhibit proliferation of mammalian cells. The developed nanocomposite material can be used as an affordable and non-toxic nanomaterial to create bacteriostatic coatings that are safe for humans.
Keywords: nanocomposite polymer material; PLGA; silver oxide nanoparticles; reactive oxygen species; bacteriostatic properties nanocomposite polymer material; PLGA; silver oxide nanoparticles; reactive oxygen species; bacteriostatic properties

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MDPI and ACS Style

Smirnova, V.V.; Chausov, D.N.; Serov, D.A.; Kozlov, V.A.; Ivashkin, P.I.; Pishchalnikov, R.Y.; Uvarov, O.V.; Vedunova, M.V.; Semenova, A.A.; Lisitsyn, A.B.; et al. A Novel Biodegradable Composite Polymer Material Based on PLGA and Silver Oxide Nanoparticles with Unique Physicochemical Properties and Biocompatibility with Mammalian Cells. Materials 2021, 14, 6915. https://doi.org/10.3390/ma14226915

AMA Style

Smirnova VV, Chausov DN, Serov DA, Kozlov VA, Ivashkin PI, Pishchalnikov RY, Uvarov OV, Vedunova MV, Semenova AA, Lisitsyn AB, et al. A Novel Biodegradable Composite Polymer Material Based on PLGA and Silver Oxide Nanoparticles with Unique Physicochemical Properties and Biocompatibility with Mammalian Cells. Materials. 2021; 14(22):6915. https://doi.org/10.3390/ma14226915

Chicago/Turabian Style

Smirnova, Veronika V., Denis N. Chausov, Dmitriy A. Serov, Valery A. Kozlov, Petr I. Ivashkin, Roman Y. Pishchalnikov, Oleg V. Uvarov, Maria V. Vedunova, Anastasia A. Semenova, Andrey B. Lisitsyn, and et al. 2021. "A Novel Biodegradable Composite Polymer Material Based on PLGA and Silver Oxide Nanoparticles with Unique Physicochemical Properties and Biocompatibility with Mammalian Cells" Materials 14, no. 22: 6915. https://doi.org/10.3390/ma14226915

APA Style

Smirnova, V. V., Chausov, D. N., Serov, D. A., Kozlov, V. A., Ivashkin, P. I., Pishchalnikov, R. Y., Uvarov, O. V., Vedunova, M. V., Semenova, A. A., Lisitsyn, A. B., & Simakin, A. V. (2021). A Novel Biodegradable Composite Polymer Material Based on PLGA and Silver Oxide Nanoparticles with Unique Physicochemical Properties and Biocompatibility with Mammalian Cells. Materials, 14(22), 6915. https://doi.org/10.3390/ma14226915

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