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Open AccessArticle

One Step Preparation of Peptide-Coated Gold Nanoparticles with Tunable Size

Key Laboratory of Clean Energy Materials Chemistry of Guangdong Higher Education Institutes, School of Chemistry and Chemical Engineering, Lingnan Normal University, Cunjin Road, Zhanjiang 524048, China
Author to whom correspondence should be addressed.
Materials 2019, 12(13), 2107;
Received: 30 April 2019 / Revised: 23 June 2019 / Accepted: 28 June 2019 / Published: 30 June 2019
(This article belongs to the Special Issue Advanced Nanomaterials and Biomaterials from Self-Assembling Peptides)
PDF [2184 KB, uploaded 30 June 2019]


Gold nanoparticles (AuNPs) made from self-assembling peptides have been used in many research fields and attracted a great deal of attention due to their high stability, biocompatibility and functionality. However, existing preparation methods for peptide-coated AuNPs are post-synthesis processes, which are complicated and time consuming. Therefore, a one-step preparation method for peptide-coated AuNPs is proposed here. The AuNPs obtained by this method exhibit good stability. Importantly, peptide-coated AuNPs with precise different sizes can be prepared by this method through pH control of reducing reagent tyrosine in range of 10.0~12.7. Thus, the one-step preparation method proposed here provides a significant tool for the research in different fields concerning NP size, stability and biocompatibility. View Full-Text
Keywords: CALNN; peptide; gold nanoparticle; self-assembling; size; tyrosine; trypsin CALNN; peptide; gold nanoparticle; self-assembling; size; tyrosine; trypsin

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Jia, Y.; Yan, X.; Guo, X.; Zhou, G.; Liu, P.; Li, Z. One Step Preparation of Peptide-Coated Gold Nanoparticles with Tunable Size. Materials 2019, 12, 2107.

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