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Case Report

Cerebral Invasive Aspergillosis in a Case of Chronic Lymphocytic Leukemia with Bruton Tyrosine Kinase Inhibitor

1
Mitchell Cancer Institute, University of South Alabama, Mobile, AL 36604, USA
2
Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35233, USA
3
O’Neal Comprehensive Cancer Center at UAB, University of Alabama at Birmingham, Birmingham, AL 35233, USA
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2021, 28(1), 837-841; https://doi.org/10.3390/curroncol28010081
Received: 9 December 2020 / Revised: 18 January 2021 / Accepted: 4 February 2021 / Published: 8 February 2021
Bruton tyrosine kinase (BTK) inhibitors have become an important therapy for untreated and previously treated patients with chronic lymphocytic leukemia (CLL). Despite improved outcomes, rare adverse events, such as invasive fungal infections, have been reported with the use of first-generation BTK inhibitors. Invasive fungal infections carry a high morbidity and mortality risk. There have been several case reports describing the association between aspergillosis and ibrutinib treatment, but none with acalabrutinib, to our knowledge. In this case report, we describe a patient with CLL who developed an intracranial Aspergillus fumigatus infection while receiving acalabrutinib. View Full-Text
Keywords: CLL; acalabrutinib; invasive aspergillosis CLL; acalabrutinib; invasive aspergillosis
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MDPI and ACS Style

Alkharabsheh, O.; Alsayed, A.; Morlote, D.M.; Mehta, A. Cerebral Invasive Aspergillosis in a Case of Chronic Lymphocytic Leukemia with Bruton Tyrosine Kinase Inhibitor. Curr. Oncol. 2021, 28, 837-841. https://doi.org/10.3390/curroncol28010081

AMA Style

Alkharabsheh O, Alsayed A, Morlote DM, Mehta A. Cerebral Invasive Aspergillosis in a Case of Chronic Lymphocytic Leukemia with Bruton Tyrosine Kinase Inhibitor. Current Oncology. 2021; 28(1):837-841. https://doi.org/10.3390/curroncol28010081

Chicago/Turabian Style

Alkharabsheh, Omar, Alhareth Alsayed, Diana M. Morlote, and Amitkumar Mehta. 2021. "Cerebral Invasive Aspergillosis in a Case of Chronic Lymphocytic Leukemia with Bruton Tyrosine Kinase Inhibitor" Current Oncology 28, no. 1: 837-841. https://doi.org/10.3390/curroncol28010081

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