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Current Oncology
Volume 25
Issue 5
10.3747/co.25.4002
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Current Oncology is published by MDPI from Volume 28 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Multimed Inc..
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Review

Radiation Therapy and Immunotherapy—A Potential Combination in Cancer Treatment

by
N. Asna
1,
A. Livoff
2,
R. Batash
3,*,
R. Debbi
3,
P. Schaffer
4,
T. Rivkind
1 and
M. Schaffer
1
1
Department of Oncology, Barzilai Medical Center, Ashkelon, and Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
2
Department of Pathology, Barzilai Medical Center, Ashkelon, and Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
3
Department of Orthopedic Surgery, Barzilai Medical Center, Ashkelon, and Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
4
Department of Radiation Therapy, Bad Trissl, Oberaudorf, Germany, and Faculty of Medicine, University of Oradea, Oradea, Romania
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2018, 25(5), 454-460; https://doi.org/10.3747/co.25.4002
Submission received: 3 July 2018 / Revised: 5 August 2018 / Accepted: 9 September 2018 / Published: 1 October 2018

Abstract

Background: Radiation therapy (RT) is a longstanding treatment modality for cancer. In addition, immune checkpoint blockade has been a significant development in the field of immunotherapy, modifying key immunosuppressive pathways of cancer cells. Methods: The aim of the present work was to review current concepts of RT and immunotherapy synergism, the abscopal effect, and the molecular effects of RT in the tumour microenvironment, its influence on immune stimulation, and potential clinical outcomes that might evolve from ongoing studies. We also discuss potential predictors of clinical response. Results: Up-to-date literature concerning the mechanisms, interactions, and latest knowledge about RT and immunotherapy was reviewed and summarized, and is presented here. Conclusions: The possibility of using hyperfractionated RT to combine an abscopal effect with the enhanced effect of immune treatment using checkpoint blockade is a very promising method for future tumour treatments.
Keywords: radiation therapy; abscopal effect; immunotherapy; checkpoint blockade; combination therapy; PD-L1 radiation therapy; abscopal effect; immunotherapy; checkpoint blockade; combination therapy; PD-L1

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MDPI and ACS Style

Asna, N.; Livoff, A.; Batash, R.; Debbi, R.; Schaffer, P.; Rivkind, T.; Schaffer, M. Radiation Therapy and Immunotherapy—A Potential Combination in Cancer Treatment. Curr. Oncol. 2018, 25, 454-460. https://doi.org/10.3747/co.25.4002

AMA Style

Asna N, Livoff A, Batash R, Debbi R, Schaffer P, Rivkind T, Schaffer M. Radiation Therapy and Immunotherapy—A Potential Combination in Cancer Treatment. Current Oncology. 2018; 25(5):454-460. https://doi.org/10.3747/co.25.4002

Chicago/Turabian Style

Asna, N., A. Livoff, R. Batash, R. Debbi, P. Schaffer, T. Rivkind, and M. Schaffer. 2018. "Radiation Therapy and Immunotherapy—A Potential Combination in Cancer Treatment" Current Oncology 25, no. 5: 454-460. https://doi.org/10.3747/co.25.4002

APA Style

Asna, N., Livoff, A., Batash, R., Debbi, R., Schaffer, P., Rivkind, T., & Schaffer, M. (2018). Radiation Therapy and Immunotherapy—A Potential Combination in Cancer Treatment. Current Oncology, 25(5), 454-460. https://doi.org/10.3747/co.25.4002

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