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Current Oncology
Volume 24
Issue 3
10.3747/co.24.3509
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Current Oncology is published by MDPI from Volume 28 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Multimed Inc..
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Case Report

Molecular Progression in Unusual Recurrent Non-Pediatric Intracranial Clear Cell Meningioma

by
B. Domingo-Arrué
1,
Rosario Gil-Benso
1,*,
J. Megías
1,
L. Navarro
1,
T. San-Miguel
1,
L. Muñoz-Hidalgo
2,
C. López-Ginés
1 and
M. Cerdá-Nicolás
1,2
1
Departamento de Patología, Universitat de València, Avinguda Blasco Ibáñez, 15, 46010 Valencia, Spain
2
INCLIVA, Clinic Hospital of Valencia, Valencia, Spain
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2017, 24(3), 244-250; https://doi.org/10.3747/co.24.3509
Submission received: 4 March 2017 / Revised: 5 April 2017 / Accepted: 5 May 2017 / Published: 1 June 2017

Abstract

We report a case of a recurrent clear cell meningioma (CCM) in the frontal lobe of the brain of a 67-year-old man. The patient developed three recurrences: at 3, 10, and 12 years after his initial surgery. Histopathology observations revealed a grade 2 CCM with positivity for vimentin and epithelial membrane antigen. Expression of E-cadherin was positive only in the primary tumour and in the first available recurrence. Fluorescence in situ hybridization analyses demonstrated 1p and 14q deletions within the last recurrence. Multiplex ligation-dependent probe amplification studies revealed a heterozygous partial NF2 gene deletion, which progressed to total loss in the last recurrence. The last recurrence showed homozygous deletions in CDKN2A and CDKN2B. The RASSF1 gene was hypermethylated during tumour evolution. In this report, we show the genetic alterations of a primary ccm and its recurrences to elucidate their relationships with the changes involved in the progression of this rare neoplasm.
Keywords: clear cell meningioma; recurrence; intracranial disease; non-pediatric disease; genetics; NF2; tumour suppressor genes; molecular progression clear cell meningioma; recurrence; intracranial disease; non-pediatric disease; genetics; NF2; tumour suppressor genes; molecular progression

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MDPI and ACS Style

Domingo-Arrué, B.; Gil-Benso, R.; Megías, J.; Navarro, L.; San-Miguel, T.; Muñoz-Hidalgo, L.; López-Ginés, C.; Cerdá-Nicolás, M. Molecular Progression in Unusual Recurrent Non-Pediatric Intracranial Clear Cell Meningioma. Curr. Oncol. 2017, 24, 244-250. https://doi.org/10.3747/co.24.3509

AMA Style

Domingo-Arrué B, Gil-Benso R, Megías J, Navarro L, San-Miguel T, Muñoz-Hidalgo L, López-Ginés C, Cerdá-Nicolás M. Molecular Progression in Unusual Recurrent Non-Pediatric Intracranial Clear Cell Meningioma. Current Oncology. 2017; 24(3):244-250. https://doi.org/10.3747/co.24.3509

Chicago/Turabian Style

Domingo-Arrué, B., Rosario Gil-Benso, J. Megías, L. Navarro, T. San-Miguel, L. Muñoz-Hidalgo, C. López-Ginés, and M. Cerdá-Nicolás. 2017. "Molecular Progression in Unusual Recurrent Non-Pediatric Intracranial Clear Cell Meningioma" Current Oncology 24, no. 3: 244-250. https://doi.org/10.3747/co.24.3509

APA Style

Domingo-Arrué, B., Gil-Benso, R., Megías, J., Navarro, L., San-Miguel, T., Muñoz-Hidalgo, L., López-Ginés, C., & Cerdá-Nicolás, M. (2017). Molecular Progression in Unusual Recurrent Non-Pediatric Intracranial Clear Cell Meningioma. Current Oncology, 24(3), 244-250. https://doi.org/10.3747/co.24.3509

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