Next Article in Journal
When the Patient Is Also a Carer
Previous Article in Journal
Molecular Progression in Unusual Recurrent Non-Pediatric Intracranial Clear Cell Meningioma
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Current Oncology
Volume 24
Issue 3
10.3747/co.24.3588
curroncol-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles thumb_up
...
Endorse textsms
...
Comment
Current Oncology is published by MDPI from Volume 28 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Multimed Inc..
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Case Report

Carcinoma Ex Pleomorphic Adenoma: Case Report and Options for Systemic Therapy

by
N. Chooback
1,
Y. Shen
2,
M. Jones
2,
K. Kasaian
2,
M. Martin
3,
T. Ng
4,
T. Thomson
5,
M. Marra
2,
J. Laskin
1 and
Cheryl Ho
1,*
1
Department of Medical Oncology, BC Cancer Agency, University of British Columbia, 600 West 10th Avenue, Vancouver, BC V5Z 4E6, Canada
2
BC Cancer Research Centre, Vancouver, BC, Canada
3
Department of Diagnostic Imaging, BC Cancer Agency, Vancouver, BC, Canada
4
Department of Pathology and Laboratory Medicine, Vancouver Coastal Health Research Institute, Vancouver, BC, Canada
5
Department of Pathology and Laboratory Medicine, BC Cancer Agency, Vancouver, BC, Canada
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2017, 24(3), 251-254; https://doi.org/10.3747/co.24.3588
Submission received: 4 March 2017 / Revised: 5 April 2017 / Accepted: 8 May 2017 / Published: 1 June 2017

Abstract

The most common benign salivary tumour is a pleomorphic adenoma. Transformation to malignancy, carcinoma ex pleomorphic adenoma (CXPA), occurs in 6% of cases. Management focuses on surgical resection and radiotherapy; however, rare cases require systemic management. We present the case of a 60-year-old woman with a CXPA of the left parotid gland who required systemic therapy for locally recurrent disease. Treatment options were guided by the literature concerning malignant salivary gland tumour and by whole-genome and transcriptome sequencing of the tumour. The patient received multiple systemic agents during the course of her disease, with cyclophosphamide–doxorubicin–cisplatin providing the best control (partial response). Genomeand transcriptome-directed therapy, including sorafenib and vismodegib, were utilized with limited clinical benefit. Malignant transformation in CXPA is a complex process, and therapy directed at a single tumour pathway might not be sufficient to control disease.
Keywords: carcinoma ex pleomorphic adenoma; chemotherapy; cyclophosphamide; doxorubicin; cisplatin carcinoma ex pleomorphic adenoma; chemotherapy; cyclophosphamide; doxorubicin; cisplatin

Share and Cite

MDPI and ACS Style

Chooback, N.; Shen, Y.; Jones, M.; Kasaian, K.; Martin, M.; Ng, T.; Thomson, T.; Marra, M.; Laskin, J.; Ho, C. Carcinoma Ex Pleomorphic Adenoma: Case Report and Options for Systemic Therapy. Curr. Oncol. 2017, 24, 251-254. https://doi.org/10.3747/co.24.3588

AMA Style

Chooback N, Shen Y, Jones M, Kasaian K, Martin M, Ng T, Thomson T, Marra M, Laskin J, Ho C. Carcinoma Ex Pleomorphic Adenoma: Case Report and Options for Systemic Therapy. Current Oncology. 2017; 24(3):251-254. https://doi.org/10.3747/co.24.3588

Chicago/Turabian Style

Chooback, N., Y. Shen, M. Jones, K. Kasaian, M. Martin, T. Ng, T. Thomson, M. Marra, J. Laskin, and Cheryl Ho. 2017. "Carcinoma Ex Pleomorphic Adenoma: Case Report and Options for Systemic Therapy" Current Oncology 24, no. 3: 251-254. https://doi.org/10.3747/co.24.3588

APA Style

Chooback, N., Shen, Y., Jones, M., Kasaian, K., Martin, M., Ng, T., Thomson, T., Marra, M., Laskin, J., & Ho, C. (2017). Carcinoma Ex Pleomorphic Adenoma: Case Report and Options for Systemic Therapy. Current Oncology, 24(3), 251-254. https://doi.org/10.3747/co.24.3588

Article Metrics

Back to TopTop